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Título
Gene expression profiles of human glioblastomas are associated with both tumor cytogenetics and histopathology
Autor(es)
Materia
Genetic alterations
Glioblastomas
Clasificación UNESCO
3201 Ciencias Clínicas
3201.01 Oncología
2410.07 Genética Humana
Fecha de publicación
2010
Editor
Oxford University Press
Citación
Vital, A. L., Tabernero, M. D., Castrillo, A., Rebelo, O., Tão, H., Gomes, F., Nieto, A. B., Oliveira, C. R., Lopes, M. C., & Orfao, A. (2010). Gene expression profiles of human glioblastomas are associated with both tumor cytogenetics and histopathology [Review of Gene expression profiles of human glioblastomas are associated with both tumor cytogenetics and histopathology]. Neuro-Oncology, 12(9), 991-1003. https://doi.org/10.1093/NEUONC/NOQ050
Resumen
[EN] Despite the increasing knowledge about the genetic alterations and molecular pathways involved in gliomas, few studies have investigated the association between the gene expression profiles (GEP) and both cytogenetics and histopathology of gliomas. Here, we analyzed the GEP (U133Plus2.0 chip) of 40 gliomas (35 astrocytic tumors, 3 oligodendrogliomas, and 2 mixed tumors) and their association with tumor cytogenetics and histopathology. Unsupervised and supervised analyses showed significantly different GEP in low- vs high-grade gliomas, the most discriminating genes including genes involved in the regulation of cell proliferation, apoptosis, DNA repair, and signal transduction. In turn, among glioblastoma multiforme (GBM), 3 subgroups of tumors were identified according to their GEP, which were closely associated with the cytogenetic profile of their ancestral tumor cell clones: (i) EGFR amplification, (ii) isolated trisomy 7, and (iii) more complex karyotypes. In summary, our results show a clear association between the GEP of gliomas and tumor histopathology; additionally, among grade IV astrocytoma, GEP are significantly associated with the cytogenetic profile of the ancestral tumor cell clone. Further studies in larger series of patients are necessary to confirm our observations.
URI
ISSN
1522-8517
DOI
10.1093/neuonc/noq050
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