Biokmod Bioassay ICRP models International Commission for Radiological Protection Exposure to radiation Bioensayo Modelos ICRP Exposición a la radiación
Fecha de publicación :
Pergamon Press (Nueva York, Estados Unidos)
Sánchez León, J. G. (2007). Fitting bioassay data and performing uncertainty analysis with Biokmod. "Health physics", 92 (1)
Here it is described the features included in the computer code BIOKMOD related with the ICRP Models. BIOKMOD has been applied to analyze several sources of uncertainties in the evaluation of internal exposures using the bioassay data: (i) Multiple constant and random intakes in occupational exposurestaking into account periods without intake (weekends, holidays, etc.) are evaluated, and they are compared with the chronic intakes showing that the chronic approximation is not always good; (ii) An analytical method to evaluate the statistical uncertainties associated with the biokinetic model is described; (iii) Nonlinear techniques are applied to estimate the intakes using bioassay data, where not only the quantities intaken are assumed unknown but also other non linear parameters (AMAD, f1, etc). The methods described are accompanied with examples.
Se describen las caracterísiticas incluidas en el programa BIOKMOD relacionadas con los Modelos ICRP.