http://hdl.handle.net/10366/4179 2026-04-25T22:37:50Z 2026-04-25T22:37:50Z Valero Juan, Margarita Dreiss, C. A. http://hdl.handle.net/10366/170977 2026-04-15T00:01:57Z 2014-01-01T00:00:00Z

[EN]Micelles of the triblock copolymer Pluronic F127 can encapsulate drugswith various chemical structures and their architecturehasbeenstudiedbysmallangleneutron scattering(SANS). Interactionwithaderivativeofβcyclodextrin,namely,heptakis(2,6diO methyl)βcyclodextrin(DIMEB), inducesacompletebreakupof themicelles, providinga mechanism for drug release. In the presence of drugs partitioned within the micelles, competitiveinteractionsbetweenpolymer,drugandcyclodextrinleadtoamodulationof the micellarrupture,dependingonthenatureofthedrugandtheexactcompositionoftheternary system.These interactions canbe further adjustedby temperatureandpH.While themost widelyacceptedmechanismfortheinteractionbetweenPluronicsandcyclodextrinsisthrough polypseudorotaxane (PR) formation, involving the threading of βCD on the polymer backbone, timeresolvedSANSexperimentsshowthatdemicellisationtakesplaceinlessthan 100ms, thusunambiguouslyrulingoutaninclusioncomplexbetweenthecyclodextrinandthe polymerchains.

2014-01-01T00:00:00Z