Ciencias Biosanitarias

Mental health of caregivers for people with dementia and cerebral palsy as a key determinant of caregiver burden: a multivariable analysis

2026-03-04T00:00:00Z

[EN]Informal caregiving plays a vital role in supporting dependent individuals; however, prolonged caregiving is associated with significant physical and psychological strain. Understanding factors associated with caregiver burden is essential for designing effective interventions to protect caregiver health and sustain long-term care systems. To examine the associations between psychological, physical, and contextual factors on caregiver burden and to identify variables independently associated with caregiver burden. A cross-sectional study was conducted with 73 informal caregivers of people living with dementia or cerebral palsy who required substantial assistance in daily living. Standardized instruments were used to assess caregiver burden (Zarit Burden Interview), anxiety and depression (HADS), mental health and quality of life (SF-36), pain (VAS), and physical activity (IPAQ). Hierarchical multiple regression, mediation, and moderation analyses were performed. Mental health and anxiety showed the strongest independent associations of caregiver burden (β = -0.396, p = 0.002; β = 0.243, p = 0.049, respectively), followed by musculoskeletal pain in the back and lower limbs. Patient-related variables, such as functional dependence or disability, were not directly associated with burden. Mediation analysis showed that mental health did not mediate the dependence-burden link. Moderation analysis did not reveal a statistically significant interaction effect. The final model explained over 60% of the variance in caregiver burden. Caregiver mental health is a key determinant of perceived burden of caring for people with dementia and cerebral palsy, exerting a stronger influence than patient dependence or physical demands. Interventions should integrate psychological screening and mental health support to prevent caregiver distress and ensure a sustainable informal care.

Sex-dependent modulation of CGRPergic neurovascular activity by 5-CT in rats

2026-04-28T00:00:00Z

[EN]Background and purpose: Serotonin modulates vascular tone both directly and indirectly through autonomic and sensory nerves innervating blood vessels. Perivascular sensory nerves release calcitonin gene-related peptide (CGRP), a potent vasodilator strongly implicated in migraine pathophysiology. In male rats, the serotonergic system inhibits CGRPergic vasodepressor responses via 5-HT1B/1F and 5-HT7 receptors. Since both serotonergic and CGRPergic pathways exhibit marked sex differences, the present study investigated the 5-HT receptor (sub)types involved in the 5-carboxamydotryptamine (5−CT, 5-HT1/5/7 receptor agonist) modulation of vascular CGRPergic neurotransmission in rats, focusing on sex-dependent differences. Methods: Male and female Wistar rats (14–16 weeks old) were pithed and pretreated with an i.v. continuous infusion of hexamethonium and methoxamine, followed by administration of 5-HT-related drugs. Mean blood pressure (MBP) and heart rate (HR) were continuously recorded throughout the experiments. Vasodepressor CGRPergic responses were elicited by electrical stimulation of the sensory outflow (0.1–5 Hz) or i.v. α-CGRP (0.1–1 μg/kg). Results: Basal MBP and HR were lower in females than in males, whereas the methoxamine-induced increase in MBP was greater in females. The electrically evoked vasodepressor responses, as well as their inhibition by 5−CT, were similar in both sexes. In males, the inhibitory effect of 5−CT was reproduced by 5-HT1B, 5-HT1F, and 5-HT7 receptor agonists (CP-93,129, LY344864, and AS-19, respectively) and persisted in the presence of the 5-HT5A receptor antagonist SB699551. In contrast, in females, 5-CT-induced inhibition was mimicked by 5-HT1F and 5-HT7 receptor agonists and was not affected by administration of SB699551. None of the other 5-HT receptor agonists (5-HT1A/1B/1D) modified the CGRPergic vasodilator responses in females. Only AS-19 reduced the vasodepressor responses elicited by exogenous α-CGRP in females. Conclusion: 5−CT inhibits perivascular sensory CGRPergic neurotransmission in both male and female rats. Unlike males, where the 5−CT effect is mediated by prejunctional 5-HT1B/1F/7 receptors, in females, this inhibitory effect is mediated by prejunctional 5-HT1F and pre and/or postjunctional 5-HT7 receptors. These findings provide novel insights into sex-specific serotonergic modulation of neurovascular function.

Angiotensin II and EDH pathways underlie the vascular sympatho-modulation by 5-HT in female rats

2025-10-01T00:00:00Z

[EN]The vascular 5-HT sympatho-modulation may involve inhibitory or potentiating pathways: nitric oxide (NO), endothelium-dependent hyperpolarization (EDH)-K+ channels, prostanoids, angiotensin II (Ang-II), or endothelin. Compared to males, female rats show differences in the serotonergic sympatho-regulation; therefore, we aimed to study the involvement of indirect pathways via 5-HT1D-mediated inhibition and 5-HT2A/3-mediated potentiation of vascular noradrenergic neurotransmission in females. An i.v. bolus of different inhibitors/blockers of modulators/mediators (NO, K+ channels, prostanoids, Ang-II, or endothelin) was administered prior to the infusion of the agonists, L-694,247 (5-HT1D), TCB-2 (5-HT2A), or 1-PBG (5-HT3), in female pithed rats. In these conditions, the vascular sympathetic outflow was electrically stimulated to assess the vasopressor responses. The L-694,247 vascular sympatho-inhibition was abolished by a non-selective K+ channel blocker, tetraethylammonium. The 1-PBG sympatho-excitatory vascular effect was not modified by any of the inhibitors tested, whereas TCB-2 sympatho-potentiation was blocked solely by losartan (Ang-II type 1 receptor antagonist). Moreover, Ang-II levels were increased after TCB-2 infusion in females. The EDH pathway mediates the 5-HT1D-induced sympatho-inhibition, while the 5-HT2A-evoked sympatho-excitatory effect is associated with Ang-II. In contrast, the 5-HT3 sympatho-potentiation does not involve any indirect pathway. These findings advance current understanding of the complex interactions between 5-HT and vascular homeostasis in female rats.

Effectiveness of a multiple health-behaviour-change intervention in increasing adherence to the Mediterranean Diet in adults (EIRA study): a randomized controlled hybrid trial

2022-11-19T00:00:00Z

[ENG]The present study describes the effectiveness of a complex intervention that addresses multiple lifestyles to promote healthy behaviours in increasing adherence to the Mediterranean diet (MD). METHODS: Cluster-randomised, hybrid clinical trial controlled with two parallel groups. The study was carried out in 26 primary Spanish healthcare centres. People aged 45-75 years who presented at least two of the following criteria were included: smoker, low adherence to the MD or insufficient level of physical activity. The intervention group (IG) had three different levels of action: individual, group, and community, with the aim of acting on the behaviours related to smoking, diet and physical activity at the same time. The individual intervention included personalised recommendations and agreements on the objectives to attain. Group sessions were adapted to the context of each healthcare centre. The community intervention was focused on the social prescription of resources and activities performed in the environment of the community of each healthcare centre. Control group (CG) received brief advice given in the usual visits to the doctor's office. The primary outcome was the change, after 12 months, in the number of participants in each group with good adherence to the MD pattern. Secondary outcomes included the change in the total score of the MD adherence score (MEDAS) and the change in some cardiovascular risk factors. Three thousand sixty-two participants were included (IG = 1,481, CG = 1,581). Low adherence to the MD was present in 1,384 (93.5%) participants, of whom 1,233 initiated the intervention and conducted at least one individual visit with a healthcare professional. A greater increase (13.7%; 95% CI, 9.9-17.5; p < 0.001) was obtained by IG in the number of participants who reached 9 points or more (good adherence) in the MEDAS at the final visit. Moreover, the effect attributable to the intervention obtained a greater increase (0.50 points; 95% CI, 0.35 to 0.66; p < 0.001) in IG. A complex intervention modelled and carried out by primary healthcare professionals, within a real clinical healthcare context, achieved a global increase in the adherence to the MD compared to the brief advice. ClinicalTrials.gov Identifier: NCT03136211. Retrospectively registered on 02/05/2017 https://clinicaltrials.gov/ct2/show/NCT03136211.

Study protocol of a proposed Neurofeedback-Assisted Mindfulness Training Program on symptoms of anxiety and psychological distress associated with smartphone use in young adults: a randomized controlled trial

2024-01-01T00:00:00Z

Nomophobia is a specific phobia characterized by the appearance of anxiety, nervousness, discomfort and distress when the mobile phone is not used and is considered an emerging public health problem because of the negative consequences on the physical and mental health of young people and adolescents, especially women. Neurofeedback-Assisted Mindfulness Training Programs may prove beneficials for improving self-control abilities, a key ability in addressing addictive behaviors. The main objective of this study is to evaluate the impact, in a young population aged 18-35 years, of an intervention based on Neurofeedback-Assisted Mindfulness Training Program (NAMTP) on disorders associated with problematic use of mobile phones. The effect of the intervention on the total score in the nomophobia test and habits of internet and social network use, as well as on signs of depression, anxiety and stress will be analyzed. As a secondary objective, the effect of the intervention on signs of insomnia will be analyzed. Randomized, controlled clinical-trial with two-parallel groups. 40 young adults (18-35 years) will be included and randomly assigned to Intervention Group-NAMTP or Control Group (CG). The NAMTP will include a total of 25 sessions (2-3/week) during 3-months. Each session will have a duration of 10/15 min. The instrument to be used for the neurofeedback sessions is MUSE® (InteraXon Inc.). Study variables will be collected at the baseline visit and at the final visit (3-months after randomization). During these visits, questionnaires will be administered to evaluate the main and secondary variables that will include the Smartphone Addiction Scale-Short Version, Nomophobia Questionnaire, Depression, Anxiety and Stress Scale 21-item (DASS-21) and Athens Insomnia Scale. This trial will make an important contribution to the need for evidence of effective education programs and other primary care interventions through new non-invasive interventions in reducing the risk of developing addictions to new technologies and alleviating the symptoms of discomfort associated with this problem. The project was approved by the Clinical Research Ethics Committee of the Salamanca Health Area (CEIm Code: PI 2023 071340). ClinicalTrials.gov, http://www.Clinicaltrials.gov/ct2/show/NCT06188910.

Effect of adding PCSK9 inhibitors to lipid-lowering interventions on arterial stiffness: a systematic review and meta-analysis

2024-10-01T00:00:00Z

Atherosclerosis, a leading cause of mortality, necessitates effective management of hypercholesterolemia, specifically elevated low-density lipoprotein cholesterol (LDL-C). The emergence of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) has revolutionised lipid-lowering. PCSK9i demonstrates substantial LDL-C reduction and cardiovascular benefits, particularly in statin-intolerant or nonresponsive individuals. However, the potential pleiotropic effects of PCSK9i, especially on arterial stiffness, remain a subject of investigation. This systematic review and meta-analysis seek to provide a nuanced understanding of the potential pleiotropic effects of PCSK9i, specifically on arterial health. The primary objective was to analyse the influence of PCSK9i on arterial stiffness, extending beyond traditional lipid-lowering metrics and contributing to a more comprehensive approach to cardiovascular risk reduction. A systematic search was conducted across major databases, clinical trial registries and grey literature. Inclusion criteria comprised adults in prospective cohort studies undergoing PCSK9i augmentation in lipid-lowering therapy, with a focus on arterial stiffness measured by pulse wave velocity (PWv). Random-effects meta-analyses, sensitivity analyses and meta-regression models were employed to assess the pooled effect of adding PCSK9i to lipid-lowering interventions on arterial stiffness. Five studies (158 participants) met the inclusion criteria, demonstrating a significant reduction in PWv (mean difference: -2.61 m/s [95% CI: -3.70, -1.52]; ES: -1.62 [95% CI: -2.53, -.71]) upon adding PCSK9i to lipid-lowering interventions. Subgroup analysis and meta-regression models suggested potential sex-based and baseline PWv-dependent variations, emphasising patient-specific characteristics. The meta-analysis provides robust evidence that adding PCSK9i to lipid-lowering interventions significantly improves arterial stiffness, indicating broader vascular benefits beyond LDL-C reduction.

Influence of social networks on self-image and lifestyle in postpartum women: a systematic scoping review

2025-07-12T00:00:00Z

[ENG]Postpartum is a critical phase for women's health, characterized by physical, psychological, and social changes. Social networks have emerged as a predominant communication channel, offering support and quick access to information about motherhood. However, their use can also negatively influence body image and dietary behavior, especially in a context of pro-slimness beauty standards. Postpartum women are particularly vulnerable to body dissatisfaction, but there are still few studies that specifically analyze the impact of social networks at this stage. This scoping review aims to map and describe the available evidence on how the possible influence of exposure to social media content on body image perception and the adoption of eating and exercise-related habits in women during the postpartum period has been investigated. This scoping review was conducted following the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) guidelines, adapted for exploratory reviews. We searched for studies published in the last 10-years in databases such as PubMed, Scopus, Web of Science, CINAHL, and BVS, using terms related to social networks, body image, diet, exercise, and the postpartum period. Eight studies were included after applying eligibility criteria based on the PIO framework. An assessment of the quality of methodological reporting was performed using best practice guidelines such as SRQR, STROBE, CONSORT, and PRISMA, for descriptive purposes. We analyzed 8 studies suggesting that social networks may negatively influence the body image, eating and exercise habits of postpartum women. The publications represent unrealistic aesthetic standards, associated with body dissatisfaction, restrictive diets, and intensive exercise, with prevalent nutritional misinformation. Although positive messages of body acceptance were identified, they were scarce, suggesting the need for regulation and media education. Social networks could exert a relevant influence on women's body image and self-care habits in the postpartum period, promoting unrealistic aesthetic standards that could have a negative impact on their physical and emotional well-being. It is essential to implement media literacy strategies, promote inclusive content, and regulate misinformation on these platforms to mitigate their adverse effects and promote a healthy and sustainable recovery.

Study of DNA repair gene polymorphims in ovarian cancer

2019-01-01T00:00:00Z

[ES]El trabajo presenta un estudio de asociación genética centrado en el cáncer de ovario, orientado a determinar si determinados polimorfismos en genes de reparación del ADN se relacionan con una mayor susceptibilidad a desarrollar la enfermedad y con algunas de sus características clínicas. En concreto, se analizan variantes en los genes XRCC1, APEX1, ERCC2, ERCC1, XRCC3, MLH1 y TP53 mediante genotipado TaqMan, utilizando ADN germinal de 185 pacientes con cáncer de ovario y 129 controles sanos. Los resultados indican que ciertos genotipos concretos, como el GA de XRCC1 rs1799782, el CC de TP53 rs1042522 y el GG de MLH1 rs1800734, se asocian con mayor susceptibilidad al cáncer de ovario. Además, el alelo T de APEX1 rs1130409 se vincula con aparición más tardía de la enfermedad y con cáncer de ovario hereditario, mientras que el genotipo TT de XRCC3 rs1799794 se asocia con mayor susceptibilidad en pacientes de mayor edad y en casos familiares. En conjunto, el abstract sostiene que variantes en genes de reparación del ADN distintos de BRCA1/2 también pueden influir en el riesgo y perfil clínico del cáncer de ovario.

Predominantly pro-inflammatory phenotype with mixed M1/M2 polarization of peripheral blood classical monocytes and monocyte-derived macrophages among patients with excessive ethanol intake

2023-09-01T00:00:00Z

[EN]Excessive alcohol consumption impairs the immune system, induces oxidative stress, and triggers the activation of peripheral blood (PB) monocytes, thereby contributing to alcoholic liver disease (ALD). We analyzed the M1/M2 phenotypes of circulating classical monocytes and macrophage-derived monocytes (MDMs) in excessive alcohol drinkers (EADs). PB samples from 20 EADs and 22 healthy controls were collected for isolation of CD14+ monocytes and short-term culture with LPS/IFNγ, IL4/IL13, or without stimulation. These conditions were also used to polarize MDMs into M1, M2, or M0 phenotypes. Cytokine production was assessed in the blood and culture supernatants. M1/M2-related markers were analyzed using mRNA expression and surface marker detection. Additionally, the miRNA profile of CD14+ monocytes was analyzed. PB samples from EADs exhibited increased levels of pro-inflammatory cytokines. Following short-term culture, unstimulated blood samples from EADs showed higher levels of soluble TNF-α and IL-8, whereas monocytes expressed increased levels of surface TNF-α and elevated mRNA expression of pro-inflammatory cytokines and inducible nitric oxide synthase. MDMs from EADs showed higher levels of TNF-α and CD206 surface markers and increased IL-10 production. LPS/IFNγ induced higher mRNA expression of Nrf2 only in the controls. miRNA analysis revealed a distinctive miRNA profile that is potentially associated with liver carcinogenesis and ALD through inflammation and oxidative stress. This study confirms the predominantly pro-inflammatory profile of PB monocytes among EADs and suggests immune exhaustion features in MDMs.

Targeting a Glioblastoma Cancer Stem-Cell Population Defined by EGF Receptor Variant III

2014-02-15T00:00:00Z

[EN]The relationship between mutated proteins and the cancer stem-cell population is unclear. Glioblastoma tumors frequently express EGFRvIII, an EGF receptor (EGFR) variant that arises via gene rearrangement and amplification. However, expression of EGFRvIII is restricted despite the prevalence of the alteration. Here, we show that EGFRvIII is highly coexpressed with CD133 and that EGFRvIII+/CD133+ defines the population of cancer stem cells (CSC) with the highest degree of self-renewal and tumor-initiating ability. EGFRvIII+ cells are associated with other stem/progenitor markers, whereas markers of differentiation are found in EGFRvIII− cells. EGFRvIII expression is lost in standard cell culture, but its expression is maintained in tumor sphere culture, and cultured cells also retain the EGFRvIII+/CD133+ coexpression, self-renewal, and tumor initiating abilities. Elimination of the EGFRvIII+/CD133+ population using a bispecific antibody reduced tumorigenicity of implanted tumor cells better than any reagent directed against a single epitope. This work demonstrates that a mutated oncogene can have CSC-specific expression and be used to specifically target this population.

Evolutionary Origins of Metabolic Reprogramming in Cancer

2022-10-11T00:00:00Z

[EN]Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. These changes are not specific to tumors but also take place during the physiological growth of tissues. Indeed, the cellular and tissue mechanisms present in the tumor have their physiological counterpart in the repair of tissue lesions and wound healing. These molecular mechanisms have been acquired during metazoan evolution, first to eliminate the infection of the tissue injury, then to enter an effective regenerative phase. Cancer itself could be considered a phenomenon of antagonistic pleiotropy of the genes involved in effective tissue repair. Cancer and tissue repair are complex traits that share many intermediate phenotypes at the molecular, cellular, and tissue levels, and all of these are integrated within a Systems Biology structure. Complex traits are influenced by a multitude of common genes, each with a weak effect. This polygenic component of complex traits is mainly unknown and so makes up part of the missing heritability. Here, we try to integrate these different perspectives from the point of view of the metabolic changes observed in cancer.

Monitorización farmacocinética de azoles para la personalización de la terapia antifúngica

2026-01-01T00:00:00Z

[ES] Durante los últimos años las infecciones fúngicas invasivas (IFI) han adquirido una importancia creciente en el ámbito hospitalario. En muchas ocasiones se presentan como infecciones oportunistas y comportan una elevada morbimortalidad, especialmente en algunos grupos de pacientes inmunodeprimidos como aquellos con enfermedades oncohematológicas, autoinmunes e inflamatorias, o los receptores de trasplantes de progenitores hematopoyéticos y de órgano sólido. Aunque los avances en la terapéutica han permitido disminuir de forma muy significativa la mortalidad y mejorar la calidad de vida, han supuesto un incremento del número de pacientes susceptibles al desarrollo de una IFI (1). La mejora de los métodos diagnósticos, microbiológicos y no microbiológicos (tomografía computarizada de alta resolución, galactomanano, betaglucano, etc.) ha contribuido al aumento del número de casos diagnosticados, así como a un diagnóstico más precoz. Esto, junto con la introducción de nuevos antifúngicos ha permitido que el pronóstico de las IFI haya mejorado en los últimos años (2). No obstante, estas infecciones continúan siendo un reto para los clínicos. Esta tesis tiene como objetivo la implantación en la práctica clínica de un programa de monitorización farmacocinética de antifúngicos del grupo de los triazoles en pacientes que reciben estos fármacos como profilaxis o tratamiento de IFI permite optimizar el tratamiento, aumentando la eficacia y reduciendo la toxicidad. Las decisiones terapéuticas basadas no sólo en la respuesta clínica y microbiológica, sino también en los resultados de la TDM de triazoles, contribuyen a mejorar los resultados clínicos a corto y largo plazo.

Monitorización de toxicidad aguda en un paciente anciano con adenocarcinoma de pulmón estadio III-A tratado con esquema de OT/RDT basado en docetaxel en primera línea

2008-01-01T00:00:00Z

[ES]El documento aportado corresponde al volumen Avances en el tratamiento del cáncer de pulmón no microcítico y, en el fragmento legible, desarrolla especialmente un caso clínico centrado en la monitorización de la toxicidad aguda en un paciente anciano con adenocarcinoma pulmonar estadio IIIA tratado con un esquema basado en cisplatino, docetaxel y radioterapia. El texto expone los antecedentes clínicos del paciente, la valoración clínica y geriátrica previa al tratamiento, la estrategia terapéutica adoptada, la vigilancia de toxicidades hematológicas, digestivas, renales, cutáneas y de hipersensibilidad, así como la evaluación de la respuesta tumoral. La idea principal que se desprende del documento es que la edad avanzada no debe operar por sí sola como criterio de exclusión terapéutica, siempre que exista una adecuada selección clínica del paciente, una evaluación geriátrica razonada y una monitorización estrecha de la toxicidad. En ese contexto, el tratamiento con docetaxel aparece presentado como una opción activa y potencialmente eficaz dentro del abordaje del cáncer de pulmón no microcítico localmente avanzado.

Antitumoral effect of ocoxin on acute myeloid leukemia

2016-02-02T00:00:00Z

[EN]Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy whose incidence is growing in developed countries. In the relapse setting, very limited therapeutic options are available and in most cases only palliative care can be offered to patients. The effect of a composite formulation that contains several antioxidants, Ocoxin Oral solution (OOS), was tested in this condition. When analyzed in vitro, OOS exhibited anti-AML action that was both time and dose dependent. In vivo OOS induced a ralentization of tumor growth that was due to a decrease in cell proliferation. Such effect could, at least partially, be due to an increase in the cell cycle inhibitor p27, although other cell cycle proteins seemed to be altered. Besides, OOS induced an immunomodulatory effect through the induction of IL6. When tested in combination with other therapeutic agents normally used in the treatment of AML patients, OOS demonstrated a higher antiproliferative action, suggesting that it may be used in combination with those standard of care treatments to potentiate their antiproliferative action in the AML clinic.

Intermediate molecular phenotypes to identify genetic markers of anthracycline-induced cardiotoxicity risk

2023-07-27T00:00:00Z

[EN]Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, but we cannot predict who may suffer from this complication. CDA is a complex trait with a polygenic component that is mainly unidentified. We propose that levels of intermediate molecular phenotypes (IMPs) in the myocardium associated with histopathological damage could explain CDA susceptibility, so variants of genes encoding these IMPs could identify patients susceptible to this complication. Thus, a genetically heterogeneous cohort of mice (n = 165) generated by backcrossing were treated with doxorubicin and docetaxel. We quantified heart fibrosis using an Ariol slide scanner and intramyocardial levels of IMPs using multiplex bead arrays and QPCR. We identified quantitative trait loci linked to IMPs (ipQTLs) and cdaQTLs via linkage analysis. In three cancer patient cohorts, CDA was quantified using echocardiography or Cardiac Magnetic Resonance. CDA behaves as a complex trait in the mouse cohort. IMP levels in the myocardium were associated with CDA. ipQTLs integrated into genetic models with cdaQTLs account for more CDA phenotypic variation than that explained by cda-QTLs alone. Allelic forms of genes encoding IMPs associated with CDA in mice, including AKT1, MAPK14, MAPK8, STAT3, CAS3, and TP53, are genetic determinants of CDA in patients. Two genetic risk scores for pediatric patients (n = 71) and women with breast cancer (n = 420) were generated using machine-learning Least Absolute Shrinkage and Selection Operator (LASSO) regression. Thus, IMPs associated with heart damage identify genetic markers of CDA risk, thereby allowing more personalized patient management.

Niraparib maintenance therapy in patients aged 75 years and older with platinum-sensitive recurrent ovarian cancer: a subgroup assesment of the GEICO-88R study

2023-01-01T00:00:00Z

[ES]La comunicación analiza el uso de niraparib como tratamiento de mantenimiento en pacientes de 75 o más años con cáncer de ovario recurrente sensible al platino, a partir de un subanálisis del estudio GEICO-88R. El trabajo muestra que, en esta cohorte de edad avanzada, las comorbilidades esperables fueron frecuentes, pero el tratamiento presentó una tolerancia comparable a la observada en la población general del estudio. Además, se aportan datos de supervivencia libre de progresión y de toxicidad, concluyéndose que el mantenimiento con niraparib es manejable y bien tolerado en este subgrupo, del que existe escasa información publicada.