http://hdl.handle.net/10366/4179 Thu, 23 Apr 2026 09:15:23 GMT 2026-04-23T09:15:23Z http://hdl.handle.net/10366/170977 [EN]Micelles of the triblock copolymer Pluronic F127 can encapsulate drugswith various chemical structures and their architecturehasbeenstudiedbysmallangleneutron scattering(SANS). Interactionwithaderivativeofβcyclodextrin,namely,heptakis(2,6diO methyl)βcyclodextrin(DIMEB), inducesacompletebreakupof themicelles, providinga mechanism for drug release. In the presence of drugs partitioned within the micelles, competitiveinteractionsbetweenpolymer,drugandcyclodextrinleadtoamodulationof the micellarrupture,dependingonthenatureofthedrugandtheexactcompositionoftheternary system.These interactions canbe further adjustedby temperatureandpH.While themost widelyacceptedmechanismfortheinteractionbetweenPluronicsandcyclodextrinsisthrough polypseudorotaxane (PR) formation, involving the threading of βCD on the polymer backbone, timeresolvedSANSexperimentsshowthatdemicellisationtakesplaceinlessthan 100ms, thusunambiguouslyrulingoutaninclusioncomplexbetweenthecyclodextrinandthe polymerchains. Wed, 01 Jan 2014 00:00:00 GMT http://hdl.handle.net/10366/170977 2014-01-01T00:00:00Z