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dc.contributor.authorGómez Sánchez, Leticia
dc.contributor.authorGarcía Ortiz, Luis 
dc.contributor.authorPatino Alonso, Carmen
dc.contributor.authorRecio Rodríguez, José I.
dc.contributor.authorFeuerbach, Natalia
dc.contributor.authorMarti, Ruth
dc.contributor.authorAgudo Conde, Cristina
dc.contributor.authorRodríguez Sánchez, Emiliano 
dc.contributor.authorMaderuelo Fernández, José A.
dc.contributor.authorRamos, Rafael
dc.contributor.authorGómez Marcos, Manuel A.
dc.identifier.citationGómez-Sánchez, L. García-Ortiz, L. Patino-Alonso, M.C. Recio-Rodríguez, J.I. Feuerbach, N. Marti, R. et al. (2017). Glycemic markers and relation with arterial stiffness in Caucasian subjects of the MARK study. PLoS ONE 12(4): e0175982.
dc.description.abstract[EN]BACKGROUND: Effect of prediabetes and normal glucose on arterial stiffness remains controversial. The primary aim of this study was to investigate the relationship of fasting plasma glucose (FPG), postprandial glucose (PG) and glycosylated haemoglobin (HbA1c) with brachial-ankle pulse wave velocity (baPWV) and cardio-ankle vascular index (CAVI) in Caucasian adults. The secondary aim was to analyse this relationship by glycaemic status. METHODS: Cross-sectional study. Setting: Primary care. Participants: 2,233 subjects, 35-74 years. Measures: FPG (mg/dL) and HbA1c (%) of all subjects were measured using standard automated enzymatic methods. PG (mg/dL) was self-measured at home two hours after meals (breakfast, lunch and dinner) for one day using an Accu-chek ® glucometer. CAVI was measured using a VaSera VS-1500® device (Fukuda Denshi), and baPWV was calculated using a validated equation. RESULTS: CAVI and baPWV values were significantly higher in subjects with diabetes mellitus than in glucose normal and prediabetes groups (p<0.001). FPG, PG and HbA1c were positively associated with CAVI and baPWV. The β regression coefficient for: HbA1c was 0.112 (CI 95% 0.068 to 0.155) with CAVI, 0.266 (CI 95% 0.172 to 0.359) with baPWV; for PG was 0.006 (CI 95% 0.004 to 0.009 and for FPG was 0.005 (CI 95% 0.002 to 0.008) with baPWV; and for PG was 0.002 (CI 95% 0.001 to 0.003) and 0.003 (CI 95% 0.002 to 0.004) with CAVI (p<0.01 in all cases). When analysing by hyperglycaemic status, FPG, PG and HbA1c were positively associated with CAVI and baPWV in subjects with type 2 diabetes mellitus. CONCLUSION: FPG, PG and HbA1c show a positive association with CAVI and baPWV, in Caucasian adults with intermediate cardiovascular risk factors. When analysing by hyperglycaemic status, the association is only maintained in subjects with type 2 diabetes mellitus.es_ES
dc.publisherPublic Library of Science (New York)es_ES
dc.rightsAttribution-NonCommercial-NoDerivs 4.0 International
dc.subjectCardiovascular diseaseses_ES
dc.subjectVascular Stiffnesses_ES
dc.titleGlycemic markers and relation with arterial stiffness in Caucasian subjects of the MARK studyes_ES

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