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Título
Blood–brain barrier and foetal-onset hydrocephalus, with a view on potential novel treatments beyond managing CSF flow
Autor(es)
Materia
Foetal-onset hydrocephalus
Blood–brain barrier
Cerebrospinal fluid
Cell therapy
CSF
Fecha de publicación
2017
Resumen
[EN] Despite decades of research, no compelling non-surgical therapies have been developed for foetal hydrocephalus. So
far, most efforts have pointed to repairing disturbances in the cerebrospinal fluid (CSF) flow and to avoid further brain
damage. There are no reports trying to prevent or diminish abnormalities in brain development which are inseparably
associated with hydrocephalus. A key problem in the treatment of hydrocephalus is the blood–brain barrier
that restricts the access to the brain for therapeutic compounds or systemically grafted cells. Recent investigations
have started to open an avenue for the development of a cell therapy for foetal-onset hydrocephalus. Potential cells
to be used for brain grafting include: (1) pluripotential neural stem cells; (2) mesenchymal stem cells; (3) geneticallyengineered
stem cells; (4) choroid plexus cells and (5) subcommissural organ cells. Expected outcomes are a proper
microenvironment for the embryonic neurogenic niche and, consequent normal brain development.
URI
ISSN
2045-8118
DOI
https://doi.org/10.1186/s12987-017-0067-0
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