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Título
Mutation Status and Immunoglobulin Gene Rearrangements in Patients from Northwest and Central Region of Spain with Chronic Lymphocytic Leukemia
Autor(es)
Materia
Instituto de Investigación Biomédica de Salamanca
Hematología
Ig gene expression
Chronic Lymphocytic Leukemia
Spain
Mutation Status
Fecha de publicación
2014
Citación
González-Gascón y Marín, I., Hernández, J. A., Martín, A., Alcoceba, M., Sarasquete, M. E., Rodríguez-Vicente, A., ... & De La Fuente, I. (2014). Mutation status and immunoglobulin gene rearrangements in patients from northwest and central region of Spain with chronic lymphocytic leukemia. BioMed research international, 2014.
Resumen
[EN] The aim of this study was to investigate the frequency and mutation status of the immunoglobulin heavy variable chain (IGHV)
in a cohort of 224 patients from northwest and central region of Spain diagnosed with chronic lymphocytic leukemia (CLL), and
to correlate it with cytogenetic abnormalities, overall survival (OS) and time to first treatment (TTFT). 125 patients had mutated
IGHV, while 99 had unmutated IGHV.The most frequently used IGHV family was IGHV3, followed by IGHV1 and IGHV4.The
regions IGHV3-30, IGHV1-69, IGHV3-23, and IGHV4-34 were the most commonly used. Only 3.1% of the patients belonged to
the subfamily IGHV3-21 and we failed to demonstrate a worse clinical outcome in this subgroup.TheIGHV4 family appearedmore
frequently withmutated pattern, similar to IGHV3-23 and IGHV3-74. By contrast, IGHV1-69 was expressed at a higher frequency in
unmutatedCLLpatients.All the cases fromIGHV3-11 and almost all fromIGHV5-51 subfamily belonged to the groupof unmutated
CLL.
URI
ISSN
2314-6133
DOI
10.1155/2014/257517
Versión del editor
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