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Título
Antineoplastic behavior of polydopamine nanoparticles prepared in different water/alcohol media
Autor(es)
Materia
Polydopamine nanoparticles
Alcohols
Size
Iron adsorption capacity
Cytotoxicity
Clasificación UNESCO
3303 Ingeniería y Tecnología Químicas
Fecha de publicación
2021
Editor
Colloids and Surfaces B: Biointerfaces
Citación
Nieto Jiménez, C.; Marcelo, G. [et al.] (2021). Antineoplastic behaviour of polydopamine nanoparticles prepared in different water/alcohol media. Colloids and Surfaces B: Biointerfaces, 199, pp. 111506-111515. doi: 10.1016/j.colsurfb.2020.111506
Resumen
[EN] Polydopamine nanoparticles (PD NPs) have been synthesized in the present work through the oxidative polymerization of dopamine in aqueous media containing five different types of alcohol in a constant solvent volume ratio. We have shown that the type of alcohol, along with the ammonium hydroxide concentration used in the synthesis process, conditions particle size. Additionally, it has been found that the type of alcohol employed influences the well-known capacity of polydopamine nanoparticles to adsorb iron. As a consequence, since a ferroptosis-like mechanism may account for the cytotoxicity of these nanoparticles, the type of alcohol could also have a determining role in their antineoplastic activity. Here, the existence of a correlation between the ability of polydopamine nanoparticles to load Fe3+ and their toxic effect on breast cancer cells has been proven. For instance, nanoparticles synthesized using 2-propanol adsorbed more Fe3+ and had the greatest capacity to reduce
breast tumor cell viability. Moreover, none of the nanoparticle synthesized with the different alcohols significantly decreased normal cell survival. Cancer cells present greater iron-dependence than healthy cells and this fact may explain why polydopamine nanoparticles toxicity, in which Fenton chemistry could be implicated, seems tumor-specific.
URI
ISSN
0927-7765
DOI
10.1016/j.colsurfb.2020.111506
Versión del editor
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