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Título
Genetic study in patients operated dentally and anesthetized with articaine-epinephrine
Autor(es)
Materia
Pain
Polymorphism
OPRM1
TRPV1
NOS3
IL6
Clasificación UNESCO
2409 Genética
Fecha de publicación
2019
Editor
Dove Press
Citación
López -Valverde, N., López -Valverde, A., Gómez de Riego, N., Cierza-Borrella, C., Ramirez, J. M., & González-Sarmiento, R. (2019). Genetic study in patients operated dentally and anesthetized with articaine-epinephrine. Journal of Pain Research, 12, 1371–1384. https://doi.org/10.2147/JPR.S193745
Resumen
[EN] In this study we wanted to figure out if there was a correlation between OPRM1 N40D, TRPV1 I316M, TRPV1 I585V, NOS3 -786T>C and IL6 -174C>G polymorphisms and the response to locally applied articaine-epinephrine anesthetic. Methods: In this observational study, 114 oral cell samples of patients anesthetized with articaine-epinephrine (54 from men 60 from women), were collected from dental centers in Madrid (Spain). High molecular weight DNA was obtained from oral mucosa cells. The analysis of OPRM1 N40D (rs1799971), TRPV1 I316M (rs222747), TRPV1 I585V (rs8065080) and IL6 -174C>G polymorphism was performed through real-time PCR allelic discrimination using TaqMan probes. Polymorphism NOS3 -786T> C (rs2070744) was analyzed using RFLP-PCR. The studied polymorphisms are involved neither in the response to the anesthetic, nor in the intensity of perceived dental pain.
URI
DOI
10.2147/JPR.S193745
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