Título
Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast [Dataset]
Autor(es)
Palabras clave
Fission Yeast
DNA damage
Rho1p GEF
Clasificación UNESCO
2414.10 Micología (Levaduras)
2415.01 Biología Molecular de Microorganismos
Fecha de publicación
2017
Editor
Universidad de Salamanca
Citación
Manjón, E., Edreira, T., Muñoz, S., & Sánchez, Y. (2017). Rgf1p (Rho1p GEF) is required for double-strand break repair in fission yeast [Dataset]. Nucleic acids research, 45(9), 5269–5284
Resumen
[EN]The dataset includes seven Supplementary Figure Legends about the exchange factor Rgf1p is involved in the repair of DNA double-strand breaks induced by Phl treatment. In S. pombe, the DNA damage checkpoint is activated by Rad3p (ATR homolog), which in turn activates its downstream protein kinase, Chk1p (67). The rgf1Δ cells are sensitive to CPT and highly sensitive to Phl, both drugs trigger a strong checkpoint response.
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