Limited effectiveness with a 10-day bismuth-containing quadruple therapy (Pylera®) in third-line recue treatment for Helicobacter pylori infection. A real-life multicenter study

Abstract

[EN]To assess the effectiveness, safety, and tolerance of Pylera® as a third-line in clinical practice.This was a multicenter, observational, prospective database study in four Spanish hospitals. Consecutive H. pylori-infected individuals treated with Pylera® and a proton-pump inhibitor (PPI) were invited to participate if they had failed to respond to PPI-clarithromycin-amoxicillin as first-line and to levofloxacinamoxicillin-PPI as second-line therapy. Eradication was tested 4-8 weeks after Pylera® using a C13-urea breath test. Treatment-related adverse effects (TRAEs) were assessed through a questionnaire and by reviewing databases.Of 103 subjects fulfilling the selection criteria, 101 were included in the intention-to-treat (ITT) analysis and 97 in the per-protocol (PP) analysis. In an area of high antibiotic resistance to H. pylori, 10-day Pylera® plus double-dose PPI emerged as an alternative as third-line therapy, although not achieving optimal eradication rates.