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Título
Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels
Autor(es)
Materia
Hyaline cartilage
Xenogeneic
Mesenchymal stromal cells
Elastin
Bioactive hydrogels
Mitochondrial antibody
Clasificación UNESCO
2407 Biología Celular
3213.15 Traumatología
Fecha de publicación
2017
Editor
Springer Link
Citación
Pescador, D., Ibáñez-Fonseca, A., Sánchez-Guijo, F., Briñón,J.G, Arias, F.J, Muntión, S., Hernández, C., Girotti, A., Alonso, M.,Del cañizo, M.C, Rodríguez-Cabello,C.,Blanco, J.F.(2017). Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels . J Mater Sci: Mater Med 28, 115 . https://doi.org/10.1007/s10856-017-5928-1
Resumen
[EN]Over the last decades, novel therapeutic tools for osteochondral regeneration have arisen from the combination of mesenchymal stromal cells (MSCs) and highly specialized smart biomaterials, such as hydrogel-forming elastin-like recombinamers (ELRs), which could serve as cell-carriers. Herein, we evaluate the delivery of xenogeneic human MSCs (hMSCs) within an injectable ELR-based hydrogel carrier for osteochondral regeneration in rabbits. First, a critical-size osteochondral defect was created in the femora of the animals and subsequently filled with the ELRbased hydrogel alone or with embedded hMSCs. Regeneration outcomes were evaluated after three months by gross assessment, magnetic resonance imaging and computed tomography, showing complete filling of the defect and the de novo formation of hyaline-like cartilage and subchondral bone in the hMSC-treated knees. Furthermore, histological sectioning and staining of every sample confirmed regeneration of the full cartilage thickness and early subchondral bone repair, which was more similar to the native cartilage in the case of the cell-loaded ELR-based hydrogel. Overall histological differences between the two groups were assessed semi-quantitatively
using the Wakitani scale and found to be statistically significant (p < 0.05).
URI
ISSN
0957-4530
DOI
10.1007/s10856-017-5928-1
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