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Título
Survival marker genes of colorectal cancer derived from consistent transcriptomic profiling
Autor(es)
Materia
Cancer
Colorectal cancer
Colon
Survival
Kaplan-Meier analysis
Gene marker
Bioinformatics
Transcriptomics
Gene Expression
Clasificación UNESCO
3201.01 Oncología
Fecha de publicación
2018
Editor
Springer
Citación
Martínez-Romero, J., Bueno-Fortes, S., Martín-Merino, M., Ramírez de Molina, A., De las Rivas, J.(2018) .Survival marker genes of colorectal cancer derived from consistent transcriptomic profiling . BMC Genomics 19, 857 . https://doi.org/10.1186/s12864-018-5193-9
Resumen
[EN]Identification of biomarkers associated with the prognosis of different cancer subtypes is critical to achieve better therapeutic assistance. In colorectal cancer (CRC) the discovery of stable and consistent survival markers remains a challenge due to the high heterogeneity of this class of tumors.We built an integrated dataset with 1273 human colorectal samples, which provides a homogeneous robust framework to analyse genome-wide expression and survival data. Using this dataset we identified two sets of genes that are candidate prognostic markers for CRC in stages III and IV, showing either up-regulation correlated with poor prognosis or up-regulation correlated with good prognosis.Finally, the set of top 100 genes that showed overexpression correlated with low survival was used to build a CRC risk predictor applying a multivariate Cox proportional hazards regression analysis.
URI
DOI
10.1186/s12864-018-5193-9
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