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dc.contributor.advisorRodríguez Morán, Joaquín es_ES
dc.contributor.advisorMarcos Monleón, Laura es_ES
dc.contributor.advisorFuentes de Arriba, Ángel Luises_ES
dc.contributor.authorGarrido González, José Javier 
dc.date.accessioned2022-01-27T09:58:53Z
dc.date.available2022-01-27T09:58:53Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/10366/148400
dc.description.abstract[EN]The general objective of this Thesis is the design and synthesis of small organic molecules which mimic the oxyanion-hole scaffold found in hydrolytic enzymes. They employ this structural motif to associate anions and electronegative groups such as carbonyls from esters and amides and reduce the activation energy of many reactions in which a negatively-charged transition state is generated. These artificial oxyanion-hole mimic will be used to associate the carboxylic acid group of amino acids in order to carry out the chiral resolution of racemic mixtures of amino acids. In addition, they will be employed to catalyse the transesterification of non-activated esters by mimicking the mechanism of natural hydrolaseses_ES
dc.language.isoenges_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTesis y disertaciones académicases_ES
dc.subjectUniversidad de Salamanca (España)es_ES
dc.subjectTesis Doctorales_ES
dc.subjectAcademic dissertationses_ES
dc.subjectCatálisis orgánicaes_ES
dc.subjectReceptoreses_ES
dc.titleReceptores moleculares que simulan agujeros oxianiónicos: reconocimiento molecular y catálisises_ES
dc.typeinfo:eu-repo/semantics/doctoralThesises_ES
dc.subject.unesco2306 Química Orgánicaes_ES
dc.identifier.doi10.14201/gredos.148400
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional