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Título
Thermodynamic performance of coupled enzymatic reactions: A chemical kinetics model for analyzing cotransporters, ion pumps, and ATP synthases
Autor(es)
Materia
ATP synthase
Molecular energy converters
Coupled enzymes
Thermodynamic optimization
Irreversible thermodynamics
Clasificación UNESCO
2210.03 Cinética Química
Fecha de publicación
2023-02
Resumen
[EN]Previous research has suggested that molecular energy converters such as ATP synthases, ion pumps, and
cotransporters operate via spatially separate pathways for free energy donor and acceptor reactions linked by a
protein molecule. We present a chemical kinetics model based on these works, with the basic assumption that all
molecular energy converters can be thought of as linked enzymatic reactions, one running downhill the chemical
potential gradient and driving the other uphill. To develop the model we first look at how an enzyme process can
be forced to go backwards using a basic kinetic model. We then use these findings to suggest a thermodynamically
consistent method of linking two enzymatic reactions. Finally, in the context of the aforementioned energy
converters, the thermodynamic performance of the resulting model is thoroughly investigated and the obtained
results are contrasted with experimental data.
URI
ISSN
0301-4622
DOI
10.1016/j.bpc.2022.106932
Versión del editor
Colecciones
- GIOETFE. Artículos [48]