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dc.contributor.authorHernández, José Ángel
dc.contributor.authorRodríguez-Vicente, Ana E. 
dc.contributor.authorGonzález Díaz, Marcos 
dc.contributor.authorBenito Sánchez, Rocío 
dc.contributor.authorFontanillo Fontanillo, Celia
dc.contributor.authorSandoval, Virgilio
dc.contributor.authorRomero, Mercedes
dc.contributor.authorMartín-Núñez, Guillermo
dc.contributor.authorGarcía de Coca, Alfonso
dc.contributor.authorFisac, Rosa
dc.contributor.authorGalende, Josefina
dc.contributor.authorRecio, Isabel
dc.contributor.authorOrtuño, Francisco José
dc.contributor.authorGarcía Alonso, Juan Luis 
dc.contributor.authorRivas Sanz, Javier de las
dc.contributor.authorGutiérrez Gutiérrez, Norma Carmen 
dc.contributor.authorSan Miguel Izquierdo, Jesús Fernando
dc.contributor.authorHernández, Jesús María
dc.identifier.citationHernández, J.A., Rodríguez, A.E., González, M., Benito, R., Fontanillo, C., Sandoval, V., Romero, M., Martín-Nuñez, G., García de Coca, A., Fisac, R., Galende, J., Recio, I., Ortuño, F., García, J.L., Rivas, J., Carmen Gutiérrez, N.C., San Miguel, J.F., Hernández, J.M. (2009). A high number of losses in 13q14 chromosome band is associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemia. Haematologica, 94 (3) pp 364-371.
dc.description.abstract[EN]Background Among patients with B-cell chronic lymphoid leukemia, those with 13q14 deletion have a favorable outcome. However, whether the percentage of cells with 13q- influences the prognosis or the biological characteristics of this disease is unknown. We analyzed the clinico-biological characteristics and outcome of patients with B-cell chronic lymphoid leukemia with loss of 13q as the sole cytogenetic aberration.Design and Methods Three hundred and fifty patients with B-cell chronic lymphoid leukemia were studied. Clinical data were collected and fluorescence in situ hybridization and molecular studies were carried out. In addition, a gene expression profile was obtained by microarray-based analysis.Results In 109 out of the 350 cases (31.1%) loss of 13q was the sole cytogenetic aberration at diagnosis. In the subgroup of patients with 80% or more of cells with loss of 13q (18 cases), the overall survival was 56 months compared with not reached in the 91 cases in whom less than 80% of cells had loss of 13q (p< 0.0001). The variables included in the multivariate analysis for overall survival were the percentage of losses of 13q14 (p=0.001) and B symptoms (p=0.007). The time to first therapy in the group with 80% or more vs. less than 80% of losses was 38 months vs. 87 months, respectively (p=0.05). In the multivariate analysis the variables selected were unmutated status of IgVH (p=0.001) and a high level of β2microglobulin (p=0.003). Interestingly, these differences regarding overall survival and time to first therapy were also present when other cut-offs were considered. The gene expression profile of patients with a high number of losses in 13q14 showed a high proliferation rate, downregulation of apoptosis-related genes, and dysregulation of genes related to mitochondrial functions.Conclusions Patients with B-cell chronic lymphoid leukemia with a high number of losses in 13q14 as the sole cytogenetic aberration at diagnosis display different clinical and biological features: short overall survival and time to first therapy as well as more proliferation and less apoptosis. A quantification of the number of cells showing a genetic abnormality should, therefore, be included in the study of the prognostic factors of B-cell chronic lymphoid leukemia.es_ES
dc.publisherFondazione Ferrata Storties_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.subjectLeucemia linfocítica crónica de células Bes_ES
dc.subjectPaciente oncológicoes_ES
dc.subject.meshChromosomes *
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell *
dc.titleA high number of losses in 13q14 chromosome band is associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemiaes_ES
dc.subject.unesco6310.03 Enfermedades_ES
dc.subject.decscromosomas *
dc.subject.decsleucemia linfocítica crónica de células B *

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional