Compartir
Título
Src: coordinating metabolism in cancer
Autor(es)
Materia
Cáncer
metabolismo
glucosa
Tumor
Clasificación UNESCO
enfermedad
Fecha de publicación
2022-10-10
Resumen
Metabolism must be tightly regulated to fulfil the dynamic requirements of cancer cells during proliferation, migration, stemness and differentiation. Src is a node of several signals involved in many of these biological processes, and it is also an important regulator of cell metabolism. Glucose uptake, glycolysis, the pentose-phosphate pathway and oxidative phosphorylation are among the metabolic pathways that can be regulated by Src. Therefore, this oncoprotein is in an excellent position to coordinate and finely tune cell metabolism to fuel the different cancer cell activities. Here, we provide an up-to-date summary of recent progress made in determining the role of Src in glucose metabolism as well as the link of this role with cancer cell metabolic plasticity and tumour progression. We also discuss the opportunities and challenges facing this field.
URI
ISSN
0950-9232
DOI
10.1038/s41388-022-02487-4
Versión del editor
Colecciones
Ficheros en el ítem
Tamaño:
1.800Mb
Formato:
Adobe PDF
Descripción:
Artículo principal