Compartir
Titre
Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14
Autor(es)
Sujet
Linfocitos
Paciente
Leucemia
Caracterización molecular
Clasificación UNESCO
6310.03 Enfermedad
2410.02 Anatomía Humana
Fecha de publicación
2012
Éditeur
Board
Citación
Rodríguez-Vicente, A.E., Hernández, J.A., Benito, R., Gutiérrez, N.C. García, J.L., Hernández Sánchez, M., Risueño, A., Sarasquete, M.E., Fermiñán, E., Fisac, R., García de Coca, A., Martín-Núñez, G., Heras, N., Recio, I., Gutiérrez, O., Rivas, J., González, M., Hernández-Rivas., J.M. (2012). Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14. PLoS ONE, 7 (11) pp 1-13. https://doi.org/10.1371/journal.pone.0048485
Resumen
[EN] Background: Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a
different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells
(13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of
13q-H patients.
Design and Methods:: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy
donors.
Results: Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (.80%) showed a different level of
gene expression as compared to patients with lower percentages (,80%, 13q-L). This deregulation affected genes involved
in apoptosis and proliferation (BCR and NFkB signaling), leading to increased proliferation and decreased apoptosis in 13q-H
patients. Deregulation of several microRNAs, such as miR-15a, miR-155, miR-29a and miR-223, was also observed in these
patients. In addition, our study also suggests that the gene expression pattern of 13q-H cases could be similar to the
patients with 11q- or 17p-.
Conclusions: This study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic
leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher
percentages of 13q- cells.
URI
DOI
10.1371/journal.pone.0048485
Versión del editor
Aparece en las colecciones