Compartir
Título
Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone: A case report
Autor(es)
Materia
Diffuse-large B-cell lymphoma
Extranodal lymphoma
Non-Hodgkin lymphoma
Primary cervix B-cell lymphoma
Fecha de publicación
2017-04-13
Editor
Lippincott, Williams & Wilkins
Citación
Cubo AM, Soto ZM, Cruz MÁ, Doyague MJ, Sancho V, Fraino A, Blanco Ó, Puig N, Alcoceba M, González M, Sayagués JM. Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone: A case report. Medicine (Baltimore). 2017 May;96(19):e6846. doi: 10.1097/MD.0000000000006846. PMID: 28489772; PMCID: PMC5428606.
Resumen
[EN]Rationale: Primary lymphomas of the uterine cervix are a rare disease. They are often misdiagnosed because of their rarity and
because they can be easily confused with a squamous cell carcinoma of the cervix, as they are usually presented as exophytic mass
with vaginal bleeding as their most common symptoms. Nevertheless, considering that both the prognosis and the treatment are
completely different between them, differential diagnosis should be taken into account.
Patient concerns: A case of a 51-year-old woman with a primary diffuse large B-cell lymphoma of the cervix is presented.
Diagnoses: Diagnosis of this tumor was a challenge for pathologists and clinicians, as four biopsies were needed to achieve a final
diagnosis.
Interventions: Patient was successfully treated with combined Rituximab and chemotherapy (R-CHOP) alone.
Outcomes: Complete remission, confirmed through biopsy, was reached after six courses of chemotherapy. At 2-years follow up,
patient is alive and free of disease.
Lessons: Considering that the prognosis and treatment of primary malignant lymphoma of the cervix are completely different than
that of the squamous cell carcinoma, awareness of this disease should be considered in the differential diagnosis.
Abbreviations: CHOP = cyclophosphamide, doxorubicin, vincristine and prednisolone, CT scan = computerized tomography
scan, ECOG = Eastern cooperative oncology group, FIGO = International Federation of Gynecology and Obstetrics, IPI =
International prognostic index, LLL = lymphoma-like lesions, MALT-lymphoma = mucosa-associated lymphoid tissue lymphoma,
MRI = magnetic resonance imaging, NHL = non-Hodgkin lymphomas, R-CHOP = rituximab, cyclophosphamide, doxorubicin,
vincristine, and prednisolone.
URI
ISSN
0025-7974
DOI
10.1097/MD.0000000000006846
Versión del editor
Colecciones
Ficheros en el ítem
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.