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Título
Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
Autor(es)
Palabras clave
Inhibidores
Sinapsis
Interneurons
Función cerebral
Procesamiento de la información
Clasificación UNESCO
2490 Neurociencias
2410 Biología Humana
Fecha de publicación
2019-01-25
Resumen
How neuronal connections are established and organized into functional networks determines brain function. In the mammalian cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made toward parsing interneuron diversity, yet the molecular mechanisms by which interneuron-specific connectivity motifs emerge remain unclear. In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons.
URI
ISSN
0036-8075
DOI
10.1126/science.aau8977
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