[EN]Acute respiratory distress syndrome (ARDS) is a severe pulmonary disease, which is one of
the major complications in COVID-19 patients. Dysregulation of the immune system and
imbalances in cytokine release and immune cell activation are involved in SARS-CoV-2
infection. Here, the inflammatory, antigen, and auto-immune profile of patients presenting
COVID-19-associated severe ARDS has been analyzed using functional proteomics
approaches. Both, innate and humoral responses have been characterized through
acute-phase protein network and auto-antibody signature. Severity and sepsis by
SARS-CoV-2 emerged to be correlated with auto-immune profiles of patients and define
their clinical progression, which could provide novel perspectives in therapeutics
development and biomarkers of COVID-19 patients. Humoral response in COVID-19
patients’ profile separates with significant differences patients with or without ARDS.
Furthermore, we found that this profile can be correlated with COVID-19 severity and
results more common in elderly patients.
