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Titre
CLL-like B-lymphocytes are systematically present at very low numbers in peripheral blood of healthy adults
Autor(es)
Sujet
Chronic lymphocytic leukemia
Diagnóstico
Clasificación UNESCO
32 Ciencias Médicas
3205.04 Hematología
Fecha de publicación
2011
Éditeur
Springer Nature
Citación
Almeida, Nieto, Teodosio, Pedreira, López, Fernández-Navarro, Nieto, Rodríguez-Caballero, Mũoz-Criado, Jara-Acevedo, Romero, & Orfao. (2011). CLL-like B-lymphocytes are systematically present at very low numbers in peripheral blood of healthy adults. Leukemia, 25(4), 718-722. https://doi.org/10.1038/LEU.2010.305
Resumen
[EN] Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in the Western world. The disease is typically diagnosed in adults >40 years old, who show an expansion (>5 × 109 cells per l) of clonal B-cells with a unique CD5+, CD23+, B-cell receptor (BCR)low immunophenotype in peripheral blood (PB) and bone marrow, frequently in association with involvement of other lymphoid tissues, disease symptoms and a heterogeneous clinical outcome. In parallel, monoclonal B-cell lymphocytosis (MBL), typically characterized by an expansion of clonal CLL-like B-cells (<5 × 109 cells per l), has been also frequently reported in otherwise asymptomatic subjects.1, 2 Increasing evidence suggests that this could represent a pre-leukemic condition, as CLL frequently develops in individuals with previous history of MBL, and MBL cases progress to CLL at a rate of 1% per year.
URI
ISSN
1476-5551
DOI
10.1038/leu.2010.305
Versión del editor
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