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Título
Interactions between genes and the environment. Epigenetics in allergy.
Autor(es)
Materia
Allergy
Epigenetics
Methylation
lencing
Treatment
Clasificación UNESCO
3207.01 Alergias
2409 Genética
Fecha de publicación
2007-11
Editor
Elservier
Citación
Isidoro-García M, Dávila-González I, Pascual de Pedro M, Sanz-Lozano C, Lorente-Toledano F. Interactions between genes and the environment. Epigenetics in allergy. Allergol Immunopathol (Madr). 2007 Nov-Dec;35(6):254-8. doi: 10.1157/13112992. PMID: 18047817.
Resumen
[EN] Epigenetics is defined as those inheritable changes occurring in gene expression, without actual modification in the genic DNA sequence. Epigenetic factors are chemically stable, potentially reversible, and can be modulated or induced by environmental factors. In the case of allergic disease, epigenetics could explain not only the discordances observed between monozygous twins but also phenomena such as incomplete penetrance, variable expression, gender and progenitor effects, and sporadic cases. In this sense, the hypothesis of hygiene is of great relevance in that it integrates genetic and epidemiological data in the context of environmental exposures. Among the different epigenetic factors, mention must be made of DNA methylation, covalent histone modifications, and other mechanisms that include different protein complexes and RNA-mediated modifications. The regulatory effect of these phenomena upon immune response has important implications for allergic diseases. At present, different lines of pharmacological research are being conducted, based on the modulation of epigenetic factors, modifying expression of the genes that encode for proteins implicated in allergic processes. Among such modulators, mention can be made of antisense oligonucleotides, ribozymes and interference RNA. The applications of epigenetics to the diagnosis and treatment of allergic disorders offer a very promising future of this specialty.
URI
ISSN
0301-0546
DOI
10.1157/13112992
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