Genomic profile of sporadic colorectal cancer liver metastases versus primary tumors as defined by high-density microarray techniques

Abstract

[EN]Currently, it is estimated that 90% of all sporadic colorectal cancer (sCRC) related deaths are (directly or indirectly) related to metastatic dissemination of the tumor. In fact, resection of localized lesions from primary non-metastatic tumors is associated with a favorable outcome, while in cases in whom metastases have occurred, complete cure is unlikely. It is now well-established that the development and progression of any neoplasia is associated with an accumulation alterations. In recent years, important advances have been achieved in sCRC tumors as regards the identification of their specific chromosomal abnormalities, as well as the precise patterns of intratumoral clonal evolution pathways associated with the metastatic process