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Analysis of interaction between dendriplexes and bovine serum albumin.
dc.contributor.authorShcharbin, Dzmitry
dc.contributor.authorPedziwiatr, Elzbieta
dc.contributor.authorChonco, Louis
dc.contributor.authorBermejo Martín, Jesús Francisco 
dc.contributor.authorOrtega, Paula
dc.contributor.authorde la Mata, F Javier
dc.contributor.authorEritja, Ramon
dc.contributor.authorGómez, Rafael
dc.contributor.authorKlajnert, Barbara
dc.contributor.authorBryszewska, Maria
dc.contributor.authorMuñoz-Fernandez, Ma Angeles
dc.date.accessioned2024-12-12T10:01:41Z
dc.date.available2024-12-12T10:01:41Z
dc.date.issued2007-07
dc.identifier.citationShcharbin, D., Pedziwiatr, E., Chonco, L., Bermejo-Martín, J. F., Ortega, P., de la Mata, F. J., ... & Muñoz-Fernandez, M. A. (2007). Analysis of interaction between dendriplexes and bovine serum albumin. Biomacromolecules, 8(7), 2059-2062.es_ES
dc.identifier.issn1525-7797
dc.identifier.urihttp://hdl.handle.net/10366/161089
dc.description.abstract[EN] Dendrimers are new nanotechnological carriers for gene delivery. Short oligodeoxynucleotides (ODNs) are a new class of antisense therapy drugs for cancer and infectious or metabolic diseases. The interactions between short oligodeoxynucleotides (GEM91, CTCTCGCACCCATCTCTCTCCTTCT; SREV, TCGTCGCTGTCTCCGCTTCTTCCTGCCA; unlabeled or fluorescein-labeled), novel water-soluble carbosilane dendrimers, and bovine serum albumin were studied by fluorescence and gel electrophoresis. The molar ratios of the dendrimer/ODN dendriplexes ranged from 4 to 7. The efficiency of formation and stability of the dendriplexes depended on electrostatic interactions between the dendrimer and the ODNs. Dendriplex formation significantly decreased the interactions between ODNs and albumin. Thus, the formation of dendriplexes between carbosilane dendrimers and ODNs may improve ODN delivery.es_ES
dc.language.isoenges_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBase Sequencees_ES
dc.subjectDNA Primerses_ES
dc.subjectDendrimerses_ES
dc.subjectSerum Albumin, Bovinees_ES
dc.subjectSpectrometry, Fluorescencees_ES
dc.subject.meshDendrimers *
dc.subject.meshBase Sequence *
dc.subject.meshDNA Primers *
dc.subject.meshSerum Albumin *
dc.titleAnalysis of interaction between dendriplexes and bovine serum albumin.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publishversionhttps://doi.org/10.1021/BM070333Pes_ES
dc.identifier.doi10.1021/bm070333p
dc.relation.projectIDCTQ2005-00795/BQUes_ES
dc.relation.projectIDSAF-2004-06778es_ES
dc.relation.projectIDSAF-2003-09209es_ES
dc.relation.projectIDRIS G03/173es_ES
dc.relation.projectIDPI061479es_ES
dc.relation.projectIDFIPSE (Grant 36514/05)es_ES
dc.relation.projectIDGrant BQU2004-02048es_ES
dc.relation.projectIDBM04-52-0es_ES
dc.relation.projectIDCM04/00136es_ES
dc.relation.projectIDMarie Curie International Incoming Fellowship (Grant 510018)es_ES
dc.relation.projectIDKasa Mianowski Fundes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES
dc.identifier.pmid17583948
dc.journal.titleBiomacromoleculeses_ES
dc.volume.number8es_ES
dc.issue.number7es_ES
dc.page.initial2059es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.decssecuencia de bases *
dc.subject.decsalbúmina sérica *
dc.subject.decsdendrímeros *
dc.subject.decscebadores de ADN *


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