Título
Emergency Surgery of the Abdominal Aorta in a Porcine Model: Two Sequential Experiments
Autor(es)
Palabras clave
Emergency Surgery
Abdominal aorta
Porcine model
Animal experiments
Clasificación UNESCO
3213.01 Cirugía Abdominal
Fecha de publicación
2008
Editor
Wiley
Citación
Lozano, F. S., Rodríguez, J. M., García‐Criado, F. J., Gonzalez‐Porras, J. R., Sanchez‐Guijo, F. M., Sanchez‐Conde, P., y García‐Sanchez, J. E. (2008). Emergency surgery of the abdominal aorta in a porcine model: Two sequential experiments. World Journal of Surgery, 32(4), 642-647. https://doi.org/10.1007/s00268-007-9346-2
Resumen
[EN]The aim of this study was to design an aggressive nonlethal animal model that would simulate
surgical treatment of the abdominal aorta with a view to studying the systemic inflammatory response. Fourteen pigs were subjected to two sequential experiments.
Experiment A was performed to determine the response to two degrees of hemorrhage: (A1) 40% bleeding; and (A2) 60% bleeding over 15 minutes followed by midline laparotomy and aortic dissection. Experiment B included two methods of aortic repair: (B1) aortic resection and
replacement with a prosthesis; and (B2) aortic bypass without aortic resection. In the latter two groups, suprarenal aortic cross-clamping was placed for 30 minutes after a 40% hemorrhage. We analyzed various inflammatory markers and mortality. The 40% bleeding (vs. 60%) elicited a smaller decrease in mean arterial pressure (110 ± 6
URI
ISSN
0364-2313
DOI
10.1007/s00268-007-9346-2
Versión del editor
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