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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice
dc.contributor.authorSotillo, Rocío
dc.contributor.authorHernando, Eva
dc.contributor.authorDíaz Rodríguez, María Elena 
dc.contributor.authorTeruya-Feldstein, Julie
dc.contributor.authorCordón-Cardo, Carlos
dc.contributor.authorLowe, Scott W
dc.contributor.authorBenezra, Robert
dc.date.accessioned2025-11-20T11:40:51Z
dc.date.available2025-11-20T11:40:51Z
dc.date.issued2007-01
dc.identifier.citationSotillo R, Hernando E, Díaz-Rodríguez E, Teruya-Feldstein J, Cordón-Cardo C, Lowe SW, Benezra R. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell. 2007 Jan;11(1):9-23. doi: 10.1016/j.ccr.2006.10.019. Epub 2006 Dec 28. PMID: 17189715; PMCID: PMC1850996.es_ES
dc.identifier.issn1535-6108
dc.identifier.urihttp://hdl.handle.net/10366/167934
dc.description.abstract[EN]Mad2 is an essential component of the spindle checkpoint that blocks activation of Separase and dissolution of sister chromatids until microtubule attachment to kinetochores is complete. We show here that overexpression of Mad2 in transgenic mice leads to a wide variety of neoplasias, appearance of broken chromosomes, anaphase bridges, and whole-chromosome gains and losses, as well as acceleration of myc-induced lymphomagenesis. Moreover, continued overexpression of Mad2 is not required for tumor maintenance, unlike the majority of oncogenes studied to date. These results demonstrate that transient Mad2 overexpression and chromosome instability can be an important stimulus in the initiation and progression of different cancer subtypes.es_ES
dc.language.isoenges_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDNAes_ES
dc.subjectCELLCYCLEes_ES
dc.subjectHUMDISEASEes_ES
dc.subject.meshChromosomal Instability *
dc.subject.meshAnimals *
dc.subject.meshHumans *
dc.subject.meshIn Situ Hybridization *
dc.subject.meshGene Expression *
dc.subject.meshMad2 Proteins *
dc.subject.meshAneuploidy *
dc.subject.meshMagnetic Resonance Imaging *
dc.subject.meshNeoplasms *
dc.subject.meshCell Cycle Proteins *
dc.subject.meshMice *
dc.titleMad2 overexpression promotes aneuploidy and tumorigenesis in micees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publishversionhttps://doi.org/10.1016/j.ccr.2006.10.019es_ES
dc.subject.unesco2302 Bioquímicaes_ES
dc.identifier.doi10.1016/j.ccr.2006.10.019
dc.relation.projectID5R01CA124378-10es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.pmid17189715
dc.journal.titleCancer celles_ES
dc.volume.number11es_ES
dc.issue.number1es_ES
dc.page.initial9es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.decsaneuploidía *
dc.subject.decsinestabilidad cromosómica *
dc.subject.decsneoplasias *
dc.subject.decshibridación in situ *
dc.subject.decsimagen por resonancia magnética *
dc.subject.decsanimales *
dc.subject.decshumanos *
dc.subject.decsratones *
dc.subject.decsproteínas Mad2 *
dc.subject.decsproteínas del ciclo celular *
dc.subject.decsexpresión génica *


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