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Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo
dc.contributor.authorDíaz Rodríguez, María Elena 
dc.contributor.authorSotillo, Rocio
dc.contributor.authorSchvartzman, Juan-Manuel
dc.contributor.authorBenezra, Robert
dc.date.accessioned2025-11-20T13:40:09Z
dc.date.available2025-11-20T13:40:09Z
dc.date.issued2008-10-28
dc.identifier.citationDiaz-Rodríguez E, Sotillo R, Schvartzman JM, Benezra R. Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16719-24. doi: 10.1073/pnas.0803504105. Epub 2008 Oct 21. PMID: 18940925; PMCID: PMC2570608.es_ES
dc.identifier.urihttp://hdl.handle.net/10366/167952
dc.description.abstract[EN]Hec1 (Highly Expressed in Cancer 1) is one of four proteins of the outer kinetochore Ndc80 complex involved in the dynamic interface between centromeres and spindle microtubules. Its overexpression is seen in a variety of human tumors and correlates with tumor grade and prognosis. We show here that the overexpression of Hec1 in an inducible mouse model results in mitotic checkpoint hyperactivation. As previously observed with overexpression of the Mad2 gene, hyperactivation of the mitotic checkpoint leads to aneuploidy in vitro and is sufficient to generate tumors in vivo that harbor significant levels of aneuploidy. These results underscore the role of chromosomal instability as a result of mitotic checkpoint hyperactivation in the initiation of tumorigenesis.es_ES
dc.language.isoenges_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAneuploidyes_ES
dc.subjectCanceres_ES
dc.subjectChromosome instabilityes_ES
dc.subject.meshKinetochores *
dc.subject.meshMitosis *
dc.subject.meshChromosomal Instability *
dc.subject.meshDoxycycline *
dc.subject.meshMicrotubule-Associated Proteins *
dc.subject.meshGene Expression Regulation *
dc.subject.meshAneuploidy *
dc.subject.meshNeoplasms *
dc.subject.meshNuclear Proteins *
dc.subject.meshTissue Distribution *
dc.subject.meshAnimals *
dc.subject.meshCell Cycle Proteins *
dc.subject.meshMice *
dc.titleHec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivoes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.relation.publishversionhttps://doi.org/10.1073/pnas.0803504105es_ES
dc.subject.unesco2302 Bioquímicaes_ES
dc.identifier.doi10.1073/pnas.0803504105
dc.relation.projectID5R01CA124378-10es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.pmid18940925
dc.identifier.essn1091-6490
dc.journal.titleProceedings of the National Academy of Sciences of the United States of Americaes_ES
dc.volume.number105es_ES
dc.issue.number43es_ES
dc.page.initial16719es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.decsinestabilidad cromosómica *
dc.subject.decsproteínas asociadas a microtúbulos *
dc.subject.decsneoplasias *
dc.subject.decsmitosis *
dc.subject.decsratones *
dc.subject.decsproteínas nucleares *
dc.subject.decsaneuploidía *
dc.subject.decscinetocoros *
dc.subject.decsregulación de la expresión génica *
dc.subject.decsanimales *
dc.subject.decsdistribución tisular *
dc.subject.decsdoxiciclina *
dc.subject.decsproteínas del ciclo celular *


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