Effects of a resistance exercise program in patients with colorectal cancer undergoing chemotherapy treatment: a randomized controlled trial study protocol

Abstract

Colorectal cancer, a major cause of morbidity and mortality, often requires chemotherapy, which can lead to debilitating side effects such as chemotherapy-induced peripheral neuropathy (CIPN). This study aims to evaluate the benefits of a strength exercise program in reducing CIPN in colorectal cancer patients undergoing chemotherapy. Conducted as a double-blind randomized controlled trial with 44 participants, the study divides them into an intervention group (supervised resistance training and home exercises) and a control group (home exercises only). Primary outcomes will be assessed using the EORTC QLQ-CIPN20 questionnaire, while secondary outcomes include quality of life, body mass index, oxygen consumption, anxiety and depression, fatigue, sleep quality, and various blood parameters. The findings will offer valuable insights into how tailored exercise protocols can improve the quality of life, physical capacity, and treatment outcomes for colorectal cancer patients, advocating for the integration of physical exercise into standard cancer care.