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Redox feedback regulation of ANAC089 signaling alters seed germination and stress response.
dc.contributor.authorAlbertos, Pablo
dc.contributor.authorTatematsu, Kiyoshi
dc.contributor.authorMateos, Isabel
dc.contributor.authorSánchez-Vicente, Inmaculada
dc.contributor.authorFernández-Arbaizar, Alejandro
dc.contributor.authorNakabayashi, Kazumi
dc.contributor.authorNambara, Eiji
dc.contributor.authorGodoy, Marta
dc.contributor.authorFranco, José M
dc.contributor.authorSolano, Roberto
dc.contributor.authorGerna, Davide
dc.contributor.authorRoach, Thomas
dc.contributor.authorStöggl, Wolfgang
dc.contributor.authorKranner, Ilse
dc.contributor.authorPerea-Resa, Carlos
dc.contributor.authorSalinas, Julio
dc.contributor.authorLorenzo, Oscar
dc.contributor.authorFranco, José M.
dc.date.accessioned2026-01-19T10:29:00Z
dc.date.available2026-01-19T10:29:00Z
dc.date.issued2021-06-15
dc.identifier.citationAlbertos P, Tatematsu K, Mateos I, Sánchez-Vicente I, Fernández-Arbaizar A, Nakabayashi K, Nambara E, Godoy M, Franco JM, Solano R, Gerna D, Roach T, Stöggl W, Kranner I, Perea-Resa C, Salinas J, Lorenzo O. Redox feedback regulation of ANAC089 signaling alters seed germination and stress response. Cell Rep. 2021 Jun 15;35(11):109263. doi: 10.1016/j.celrep.2021.109263. PMID: 34133931; PMCID: PMC8220255.es_ES
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/10366/168981
dc.description.abstractThe interplay between the phytohormone abscisic acid (ABA) and the gasotransmitter nitric oxide (NO) regulates seed germination and post-germinative seedling growth. We show that GAP1 (germination in ABA and cPTIO 1) encodes the transcription factor ANAC089 with a critical membrane-bound domain and extranuclear localization. ANAC089 mutants lacking the membrane-tethered domain display insensitivity to ABA, salt, and osmotic and cold stresses, revealing a repressor function. Whole-genome transcriptional profiling and DNA-binding specificity reveals that ANAC089 regulates ABA- and redox-related genes. ANAC089 truncated mutants exhibit higher NO and lower ROS and ABA endogenous levels, alongside an altered thiol and disulfide homeostasis. Consistently, translocation of ANAC089 to the nucleus is directed by changes in cellular redox status after treatments with NO scavengers and redox-related compounds. Our results reveal ANAC089 to be a master regulator modulating redox homeostasis and NO levels, able to repress ABA synthesis and signaling during Arabidopsis seed germination and abiotic stress.es_ES
dc.language.isoenges_ES
dc.publisherCell Press - Editor-in-Chief (currently Shawnna Buttery for Cell Reports)es_ES
dc.subjectANAC089es_ES
dc.subjectredox regulationes_ES
dc.subjectseed germinationes_ES
dc.subjectabiotic stress responseses_ES
dc.subjectplant growth and developmentes_ES
dc.subject.meshBinding Sites *
dc.subject.meshArabidopsis *
dc.subject.meshDNA *
dc.subject.meshBase Sequence *
dc.subject.meshGene Expression Regulation *
dc.subject.meshAbscisic Acid *
dc.subject.meshNitric Oxide *
dc.subject.meshDisulfides *
dc.subject.meshTranscriptome *
dc.subject.meshSulfhydryl Compounds *
dc.subject.meshSubcellular Fractions *
dc.subject.meshDown-Regulation *
dc.subject.meshSeeds *
dc.subject.meshGene Expression Profiling *
dc.subject.meshArabidopsis Proteins *
dc.subject.meshGermination *
dc.subject.meshOxidation-Reduction *
dc.subject.meshSignal Transduction *
dc.subject.meshProtein Binding *
dc.subject.meshUp-Regulation *
dc.titleRedox feedback regulation of ANAC089 signaling alters seed germination and stress response.es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/j.celrep.2021.109263
dc.relation.projectIDBIO2017-85758-R from the Ministerio de Ciencia, Innovación y Universidades (MICIU) (Spain)es_ES
dc.relation.projectIDCSD2007-00057 (TRANSPLANTA) from the Ministerio de Ciencia, Innovación y Universidades (MICIU) (Spain)es_ES
dc.relation.projectIDSA313P18 and SA137P20 from Junta de Castilla y Leónes_ES
dc.relation.projectIDEscalera de Excelencia CLU-201804 co-funded by the P.O. FEDER of Castilla y León 2014–2020 Spaines_ES
dc.relation.projectIDEcoSeed-311840 ERC.KBBE.2012.1.1-01 EcoSeed Impacts of Environmental Conditions on Seed Qualityes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.pmid34133931
dc.identifier.essn2211-1247
dc.journal.titleCell Reportses_ES
dc.volume.number35es_ES
dc.issue.number11es_ES
dc.page.initial109263es_ES
dc.page.final109276es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.decstransducción de señales *
dc.subject.decsóxido nítrico *
dc.subject.decsoxidación-reducción *
dc.subject.decssemillas *
dc.subject.decsregulación positiva *
dc.subject.decssecuencia de bases *
dc.subject.decsunión proteica *
dc.subject.decssitios de unión *
dc.subject.decsregulación negativa *
dc.subject.decsdisulfuros *
dc.subject.decsácido abscísico *
dc.subject.decscompuestos de sulfhidrilo *
dc.subject.decsgerminación *
dc.subject.decsperfiles de expresión génica *
dc.subject.decsregulación de la expresión génica *
dc.subject.decsproteínas de arabidopsis *
dc.subject.decsADN *
dc.subject.decstranscriptoma *
dc.subject.decsArabidopsis *
dc.subject.decsfracciones subcelulares *


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