A transient mitochondrial switch underlies long lasting effects of adolescent cannabis

Pagano Zottola, Antonio C; Bolaños Hernández, Juan Pedro; Ioannidou, Christina; Manzanares-Sierra, Irene; Jiménez Blasco, Daniel; García Rodríguez, Darío; Manjarrés Raza, Israel; Julio-Kalajzić, Francisca; Di Bartolomeo, Martina; Ferreira, Guillaume; Marsicano, Giovanni; Busquets-Garcia, Arnau; Pagano Zottola, Antonio C.; Bolaños, Juan P.

doi:10.1038/s41386-026-02539-3

Título

A transient mitochondrial switch underlies long lasting effects of adolescent cannabis

Autor(es)

Pagano Zottola, Antonio C

Bolaños Hernández, Juan Pedro

Ioannidou, Christina

Manzanares-Sierra, Irene

Jiménez Blasco, Daniel

García Rodríguez, Darío

Manjarrés Raza, Israel

Julio-Kalajzić, Francisca

Di Bartolomeo, Martina

Ferreira, Guillaume

Marsicano, Giovanni

Busquets-Garcia, Arnau

Pagano Zottola, Antonio C.

Bolaños, Juan P.

Palabras clave

cannabis mitochondria adolescence

Fecha de publicación

2026-08-27

Editor

Springer Nature

Citación

Ioannidou, C., Manzanares-Sierra, I., Jimenez-Blasco, D. et al. A transient mitochondrial switch underlies long lasting effects of adolescent cannabis. Neuropsychopharmacol. (2026).

Resumen

Adolescent cannabis use produces lasting and sex-specific effects into adulthood, although poorly explained mechanistically. This study links these cannabis-induced effects to sex-dependent changes in phosphorylation of mitochondrial Complex I subunit NDUFS4 during adolescence, identifying mitochondrial pathways as causal mechanisms and potential therapeutic targets to reduce their long-term consequences.

URI

https://hdl.handle.net/10366/172662

ISSN

0893-133X

DOI

10.1038/s41386-026-02539-3

Versión del editor

https://doi.org/ 10.1038/s41386-026-02539-3

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