Fitting bioassay data and performing uncertainty analysis with Biokmod

Abstract

Here it is described the features included in the computer code BIOKMOD related with the ICRP Models. BIOKMOD has been applied to analyze several sources of uncertainties in the evaluation of internal exposures using the bioassay data: (i) Multiple constant and random intakes in occupational exposurestaking into account periods without intake (weekends, holidays, etc.) are evaluated, and they are compared with the chronic intakes showing that the chronic approximation is not always good; (ii) An analytical method to evaluate the statistical uncertainties associated with the biokinetic model is described; (iii) Nonlinear techniques are applied to estimate the intakes using bioassay data, where not only the quantities intaken are assumed unknown but also other non linear parameters (AMAD, f1, etc). The methods described are accompanied with examples.