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An agent-based clustering approach for gene selection in gene expression microarray: Profile on PlumX
Title: An agent-based clustering approach for gene selection in gene expression microarray
Authors: Ramos González, Juan
Castellanos Garzón, José A.
González Briones, Alfonso
De Paz Santana, Juan F.
Corchado Rodríguez, Juan M.
Keywords: Computer Science
Issue Date: 2017
Publisher: Springer Verlag
Citation: Interdisciplinary Sciences-Computational Life Sciences. Springer Verlag.
Abstract: Gene selection is a major research area in microarray analysis, which seeks to discover differentially expressed genes for a particular target annotation. Such genes also often called informative genes are able to differentiate tissue samples belonging to different classes of the studied disease. Despite the fact that there is a wide number of proposals, the complexity imposed by this problem remains a challenge today. This research proposes a gene selection approach by means of a clustering-based multiagent system. This proposal manages different filter methods and gene clustering through coordinated agents to discover informative gene subsets. To assess the reliability of our approach, we have used four important and public gene expression datasets, two Lung cancer datasets, Colon and Leukemia cancer dataset. The achieved results have been validated through cluster validity measures, visual analytics, a classifier and compared with other gene selection methods, proving the reliability of our proposal.
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