2026-09-15T15:07:02Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1358172025-04-30T19:34:03Zcom_10366_3992com_10366_3947com_10366_3946com_10366_3823com_10366_133043com_10366_4576col_10366_3993col_10366_135272

Ruiz Remolina, Laura Ollauri Ibáñez, Claudia Pérez Roque, Lucía Núñez Gómez, Elena Pérez Barriocanal, Fernando López-Novoa, José M. Pericacho Bustos, Miguel Rodríguez Barbero, Alicia 2017 [EN]Inflammation is associated with every health condition, and is an important component of many pathologies such as cardiovascular diseases. Circulating levels of soluble endoglin have been shown to be higher in the serum of patients with cardiovascular diseases with a significant inflammatory component. The aim of this study was to evaluate the implication of circulating soluble endoglin in the inflammatory response. For this purpose, a transgenic mouse expressing human soluble endoglin (sEng+) was employed, and three different inflammatory approaches were used to mimic inflammatory conditions in different tissues. This study shows that control sEng+ mice have a normal inflammatory state. The lung and kidney injury induced by the inflammatory agents was reduced in sEng+ mice, especially the intra-alveolar and kidney infiltrates, suggesting a possible reduction in inflammation induced by soluble endoglin. To deepen into this possible effect, the leukocyte number in the bronchoalveolar lavage and air pouch lavage was evaluated and a significant reduction of neutrophil infiltration in LPS-treated lungs and ischemic kidneys from sEng+ with respect to WT mice was observed. Additionally, the mechanisms through which soluble endoglin prevents inflammation were studied. We found that in sEng+ animals the increment of proinflammatory cytokines, TNFα, IL1β and IL6, induced by the inflammatory stimulus was reduced. Soluble endoglin also prevents the augmented adhesion molecules, ICAM, VCAM and E-selectin induced by the inflammatory stimulus. In addition, vascular permeability increased by inflammatory agents was also reduced by soluble endoglin. These results suggest that soluble endoglin modulates inflammatory-related diseases and open new perspectives leading to the development of novel and targeted approaches for the prevention and treatment of cardiovascular diseases. application/pdf http://hdl.handle.net/10366/135817 eng Public Library of Science (New York) 3209 Farmacología Circulating soluble endoglin modifies the inflammatory response in mice info:eu-repo/semantics/article TEXT Gredos. Repositorio Documental de la Universidad de Salamanca Hispana