2026-05-11T06:01:06Zhttps://gredos.usal.es/oai/requestoai:gredos.usal.es:10366/1361022025-04-30T21:15:07Zcom_10366_133436com_10366_127837com_10366_4666com_10366_3823col_10366_135874
Gestión del Repositorio Documental de la Universidad de Salamanca
author
Sánchez Arroyo, Carmen
author
González Sarmiento, Rogelio
2018-01-12T09:41:29Z
2018-01-12T09:41:29Z
FarmaJournal, 2 (2017)
2445-1355
http://hdl.handle.net/10366/136102
Regulation of epigenetic and autophagy has an important role in prostate cancer. On the one hand, the impact of epigenetic modifications is engaged in proliferation, distinction and tumors survival. Panobinostat is an intense pan-deacetylases inhibitor which can reverse epigenetic changes involved in tumour development. On the other hand, autophagy in starting phases inhibits tumorigenesis endowing anti-oncogenic functions. Nonetheless, in ending phases, spreads metastasis and chemotherapy tolerance. Chloroquine is an antimalarial, it has an antineoplasic effect which is being studying due to its autophagy inhibition. The aim of this project is to assess the cytotoxic effect of Chloroquine and Panobinostat over prostate cellular line VCAP through MTT assay, and analyse the effect of drugs, covering both; concrete and synergistic, over the cellular cycle. Because of the results obtained, it is shown that both drugs cause an antitumor effect in VCAP, being important to point out Panobinostat; it has also been shown that powerful synergetic effect is responsible of death of most cells tumour. To conclude, it would be a good treatment in patients who have been diagnosed with prostate cancer
spa
Attribution-NonCommercial-NoDerivs 3.0 Unported
autofagia
Cloroquina
epigenética
Panobinostat
cáncer de próstata
Autophagy
Chloroquine
Epigenetic
Panobinostat
Prostate cancer
Estudio de fármacos inhibidores de autofagia y epigenéticos en una línea celular de cáncer de próstata
info:eu-repo/semantics/article
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
URL
https://gredos.usal.es/bitstream/10366/136102/1/Estudio_de_farmacos_inhibidores_de_autof.pdf
File
MD5
550112956c102be71400fb0ff23161f4
232534
application/pdf
Estudio_de_farmacos_inhibidores_de_autof.pdf
URL
https://gredos.usal.es/bitstream/10366/136102/4/Estudio_de_farmacos_inhibidores_de_autof.pdf.txt
File
MD5
185c7e3f5b43be43a03ef33b92a32b2f
23039
text/plain
Estudio_de_farmacos_inhibidores_de_autof.pdf.txt