2026-09-15T22:27:40Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1382332025-04-30T20:39:26Zcom_10366_138216com_10366_4512com_10366_3823col_10366_138217

00925njm 22002777a 4500 dc Álvarez Lozano, Raquel author Aramburu Villar, Laura author Puebla Ibáñez, María Pilar author Caballero Salvador, Esther author González Díaz, Myriam author Vicente, Alba author Medarde Agustín, Manuel author Peláez Lamamie de C. Arroyo, Rafael author 2016 [EN]Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of improving their pharmacokinetic and pharmacodynamics properties. CSL have been classified according to their chemical structures and the chemical structures of the pyridine and azine containing antimitotic compounds are described. The design principles behind the structural modifications and the achieved effect on the biological activity upon inclusion of these heterocycles are also discussed. Lessons from the achievements and failures have been extracted and future perspectives delineated. http://hdl.handle.net/10366/138233 10.2174/092986732311160420104823 Pharmaceutical chemistry Pyridine Drug design Azines Antimitotics Tubulin Colchicine Antitumour Pyridine Based Antitumour Compounds Acting at the Colchicine Site