2026-09-15T13:40:07Zhttps://gredos.usal.es/oai/requestoai:gredos.usal.es:10366/1407502025-04-30T20:48:49Zcom_10366_133043com_10366_4576com_10366_3823col_10366_135272
Pérez-Belmonte, Luis M.
Moreno-Santos, Inmaculada
Gómez-Doblas, Juan J.
García-Pinilla, José M.
Morcillo-Hidalgo, Luis
Garrido-Sánchez, Lourdes
Santiago-Fernández, Concepción
Crespo-Leiro, María G.
Carrasco-Chinchilla, Fernando
Sánchez-Fernández, Pedro L.
de Teresa-Galván, Eduardo
Jiménez-Navarro, Manuel
2020-01-31T10:42:46Z
2020-01-31T10:42:46Z
2017
Pérez-Belmonte, L. M., Moreno-Santos, I., Gómez-Doblas, J. J., García-Pinilla, J. M., Morcillo-Hidalgo, L., Garrido-Sánchez, L., ... & de Teresa-Galván, E. (2017). Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure. International journal of medical sciences, 14(9), 891.
1449-1907
http://hdl.handle.net/10366/140750
10.7150/ijms.19854
[EN] Epicardial adipose tissue has been proposed to participate in the pathogenesis of heart failure. The
aim of our study was to assess the expression of thermogenic genes (Uncoupling protein 1
(UCP1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α), and
PR-domain-missing 16 (PRDM16) in epicardial adipose tissue in patients with heart failure,
stablishing the difference according to left ventricular ejection fraction (reduced or preserved).
Among the 75 patients in our study, 42.7% (n=32) had reduced left ventricular ejection fraction.
UCP1, PGC1α and PRDM16 mRNA in EAT were significantly lower in patients with reduced left
ventricular ejection fraction. Multiple regression analysis showed that age, male gender, body max
index, presence of obesity, type-2-diabetes mellitus, hypertension and coronary artery disease and
left ventricular ejection fraction were associated with the expression levels of UCP1, PGC1α and
PRDM16 mRNA. Thermogenic genes expressions in epicardial adipose tissue (UCP1: OR 0.617,
95%CI 0.103-0.989, p=0.042; PGC1α: OR 0.416, 95%CI 0.171-0.912, p=0.031; PRDM16: OR
0.643, 95%CI 0.116-0.997, p=0.044) were showed as protective factors against the presence of
heart failure with reduced left ventricular ejection fraction, and age (OR 1.643, 95%CI 1.001-3.143,
p=0.026), presence of coronary artery disease (OR 6.743, 95%CI 1.932-15.301, p<0.001) and
type-2-diabetes mellitus (OR 4.031, 95%CI 1.099-7.231, p<0.001) were associated as risk factors.
The adequate expression of thermogenic genes has been shown as possible protective factors
against heart failure with reduced ejection fraction, suggesting that a loss of functional epicardial
adipose tissue brown-like features would participate in a deleterious manner on heart metabolism.
Thermogenic genes could represent a future novel therapeutic target in heart failure.
eng
Ivyspring International Publisher
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
Instituto de Investigación Biomédica de Salamanca
Epicardial adipose tissue
Heart failure
Left ventricular ejection fraction
Thermogenic genes
Cardiología
Cardiology
Cardiology
Heart Failure
cardiología
insuficiencia cardíaca
Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
International Journal of Medical Sciences
14
9
891
895