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oai:gredos.usal.es:10366/1451822025-04-30T19:37:37Zcom_10366_4019com_10366_3947com_10366_3946com_10366_3823col_10366_4020

Influence of the number of daily pills and doses on adherence to antiretroviral treatment: a 7-year study Hernández Arroyo, María Jesús Cabrera Figueroa, Salvador Sepúlveda Correa, Rosa Amanda Valverde Merino, María Paz Luna Rodrigo, Guillermo Domínguez-Gil Hurlé, Alfonso AIDS Antiretroviral treatment adherence Daily doses HIV Pill burden Anti-Retroviral Agents 3209 Farmacología 3201 Ciencias Clínicas dosis máxima admisible antirretrovirales [EN] What is known and objective: Antiretroviral treatment (ART) is hampered by complicated regimens, high pill burden, drug–drug interactions, and frequent short- and long-term adverse effects, leading to decreased adherence. Over recent years, considerable effort has been directed at developing regimens that are less burdening. We undertook a 7-year retrospective study of the records of 264 HIV-infected subjects enrolled in a pharmaceutical care programme to document the progress made and to study the influence of the number of ART pills and doses on the level of treatment adherence. Methods: Antiretroviral dispensing records were analysed for the number of pills and doses administered and the ART adherence rate estimated. Results and discussion: In 2005, the patients took a mean of 6 2 pills daily (CI 95%: 5 9–6 6), and 92 9% of them were on a twice-a-day (BID) dosage regimen. By 2012, the mean number of pills was reduced to 4 1 (CI 95%: 3 8–4 4), and only 50 9% were on a BID regimen. No statistically significant relation was observed between number of daily pills and doses and ART adherence reached by the patients in any of the analyses performed. What is new and conclusions: There has been a continuous reduction in the number of pills and doses of antiretrovirals taken by individual patients over the last 7 years due largely to the introduction of improved treatments and regimens. More daily pills or doses was not associated with worse ART adherence in our pharmaceutical care programme. 2021-02-08T11:40:31Z 2021-02-08T11:40:31Z 2016 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Hernández Arroyo, M. J.; Cabrera Figueroa, S. E. [et al.] (2016). Influence of the number of daily pilss and doses on adherence to antiretroviral treatment: a 7-year study, 41, p.34-39. doi: 10.1111/jcpt.12343 0269-4727 http://hdl.handle.net/10366/145182 10.1111/jcpt.12343 eng https://doi.org/10.1111/jcpt.12343 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Journal of Clinical Pharmacy and Therapeutics https://gredos.usal.es/bitstream/10366/145182/7/DME_Number_Daily_Pills.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by-nc-nd/4.0/ Gredos. Repositorio Documental de la Universidad de Salamanca http://hdl.handle.net/10366/145182