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oai:gredos.usal.es:10366/1452362025-04-30T20:50:16Zcom_10366_4613com_10366_4576com_10366_3823col_10366_4615

Aguilar Ayala, Yaneri Udeh, Adanna Dutta, Kelsey Bishop, Deborah Oliver, Douglas L. Malmierca, Manuel S. 2021-02-15T08:30:12Z 2021-02-15T08:30:12Z 2015 Ayala,Y.A. ; Udeh, A. [et al.] (2015). Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus. Scientific Reports, 5(1), pp. 1-17. doi: 10.1038/srep10383 http://hdl.handle.net/10366/145236 10.1038/srep10383 2045-2322 [EN] In an ever changing auditory scene, change detection is an ongoing task performed by the auditory brain. Neurons in the midbrain and auditory cortex that exhibit stimulus-specific adaptation (SSA) may contribute to this process. Those neurons adapt to frequent sounds while retaining their excitability to rare sounds. Here, we test whether neurons exhibiting SSA and those without are part of the same networks in the inferior colliculus (IC). We recorded the responses to frequent and rare sounds and then marked the sites of these neurons with a retrograde tracer to correlate the source of projections with the physiological response. SSA neurons were confined to the non-lemniscal subdivisions and exhibited broad receptive fields, while the non-SSA were confined to the central nucleus and displayed narrow receptive fields. SSA neurons receive strong inputs from auditory cortical areas and very poor or even absent projections from the brainstem nuclei. On the contrary, the major sources of inputs to the neurons that lacked SSA were from the brainstem nuclei. These findings demonstrate that auditory cortical inputs are biased in favor of IC synaptic domains that are populated by SSA neurons enabling them to compare top-down signals with incoming sensory information from lower areas. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Cortical inputs Brainstem inputs SSA non-SSA neurons Inferior colliculus Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus info:eu-repo/semantics/article