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oai:gredos.usal.es:10366/1460852025-04-30T20:41:45Zcom_10366_137251com_10366_4512com_10366_3823col_10366_137252

Antioxidant Characterization and Biological Effects of Grape Pomace Extracts Supplementation in Caenorhabditis elegans Ayuda Durán, María Begoña González Manzano, Susana Gil-Sánchez, Irene Moreno-Arribas, M. Victoria Bartolomé, Begoña Sanz-Buenhombre, Marisa Guadarrama, Alberto Santos Buelga, Celestino González Paramás, Ana María Grape pomace C. elegans Oxidative stress ROS Lifespan Antioxidant activity [EN]The aim of this work was to evaluate the biological activity of four grape pomace (GP) extracts that are rich in polyphenols using C. elegans as an in vivo model. Different concentrations of the GP extracts were assessed for their effects on the resistance of C. elegans against thermally induced oxidative stress, accumulation of reactive oxygen species (ROS), and lifespan. The cultivation of C. elegans with relatively low concentrations of GP extracts increased their resistance against thermal stress and prolonged their lifespan, while high levels displayed detrimental effects. In the studied extracts, maximum protection was observed for levels of polyphenols around 7 to 9 µg gallic acid equivalents per cultivation plate. The obtained results suggested that small changes in the ROS levels could have beneficial effects, although further studies are required to fully understand the impact of the extracts and assayed doses on ROS levels to explain the mechanism that is involved in the observed effects. 2021-05-21T09:39:33Z 2021-05-21T09:39:33Z 2021-05-21T09:39:33Z 2019 info:eu-repo/semantics/article Ayuda -Duran, B., González-Manzano, S., Gil-Sánchez, I., Moreno-Arribas, M. V., Bartolome, B., Sanz Buenhombre, M., Guadarrama, A., Santo Buelga, C., & González-Paramás, A. M. (2019). Antioxidant Characterization and Biological Effects of Grape Pomace Extracts Supplementation in Caenorhabditis elegans. Foods, 8(2), 75. https://doi.org/10.3390/foods8020075 http://hdl.handle.net/10366/146085 10.3390/foods8020075 2304-8158 eng https://doi.org/10.3390/foods8020075 http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional Foods