2026-09-15T08:28:01Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1464262025-04-30T20:48:42Zcom_10366_133043com_10366_4576com_10366_3823col_10366_135272

Pescador Hernández, David Ibáñez-Fonseca, Arturo Sánchez-Guijo Martín, Fermín García Briñón, Jesús María Arias, Francisco Javier Muntión Olave, María Sandra Hernández Fuentevilla, Cristina Natalia Girotti, Alessandra Alonso, Matilde Cañizo Fernández-Roldán, María Consuelo del Rodríguez-Cabello, José Carlos Blanco Blanco, Juan Francisco 2021-05-26T11:01:24Z 2021-05-26T11:01:24Z 2017 Pescador, D., Ibáñez-Fonseca, A., Sánchez-Guijo, F., Briñón,J.G, Arias, F.J, Muntión, S., Hernández, C., Girotti, A., Alonso, M.,Del cañizo, M.C, Rodríguez-Cabello,C.,Blanco, J.F.(2017). Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels . J Mater Sci: Mater Med 28, 115 . https://doi.org/10.1007/s10856-017-5928-1 0957-4530 http://hdl.handle.net/10366/146426 10.1007/s10856-017-5928-1 1573-4838 [EN]Over the last decades, novel therapeutic tools for osteochondral regeneration have arisen from the combination of mesenchymal stromal cells (MSCs) and highly specialized smart biomaterials, such as hydrogel-forming elastin-like recombinamers (ELRs), which could serve as cell-carriers. Herein, we evaluate the delivery of xenogeneic human MSCs (hMSCs) within an injectable ELR-based hydrogel carrier for osteochondral regeneration in rabbits. First, a critical-size osteochondral defect was created in the femora of the animals and subsequently filled with the ELRbased hydrogel alone or with embedded hMSCs. Regeneration outcomes were evaluated after three months by gross assessment, magnetic resonance imaging and computed tomography, showing complete filling of the defect and the de novo formation of hyaline-like cartilage and subchondral bone in the hMSC-treated knees. Furthermore, histological sectioning and staining of every sample confirmed regeneration of the full cartilage thickness and early subchondral bone repair, which was more similar to the native cartilage in the case of the cell-loaded ELR-based hydrogel. Overall histological differences between the two groups were assessed semi-quantitatively using the Wakitani scale and found to be statistically significant (p < 0.05). eng Springer Link Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Hyaline cartilage Xenogeneic Mesenchymal stromal cells Elastin Bioactive hydrogels Mitochondrial antibody Mitochondrial Membranes Mesenchymal Stromal Cells Hyaline Cartilage 2407 Biología Celular 3213.15 Traumatología membranas mitocondriales cartílago hialino células del estroma mesenquimatoso Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.1007/s10856-017-5928-1 Journal of Materials Science: Materials in Medicine 28 8 115