2026-09-16T03:57:44Zhttps://gredos.usal.es/oai/requestoai:gredos.usal.es:10366/1465262025-06-05T12:36:20Zcom_10366_146467com_10366_127837com_10366_4666com_10366_3823col_10366_146468
Gestión del Repositorio Documental de la Universidad de Salamanca
author
Toro, Azahara I.
author
Jesús Valle, María José de
2021-05-27T12:03:23Z
2021-05-27T12:03:23Z
2021-04-15
FarmaJournal, 6 (2021)
2445-1355
http://hdl.handle.net/10366/146526
[EN]Liposomes provide ideal vesicular systems for controlled release and vectorization of drugs through pulmonary administration, due to their similarity to cell membranes and their great versatility. Sildenafil citrate, represents an optimal model of drug to be incorporated into these lipid vesicles for the treatment of pulmonary hypertension. The objective of the work was to characterize the behavior of liposomes loaded with sildenafil and evaluate the transfer of the drug in different bio-resistant media. Liposomes of two sizes (0.45 and 0.20 microns) were developed by sonication. Subsequently, the drug release test was carried out in different biorelevant media (simulated plasma fluid SBF, simulated pulmonary fluid SPF and PBS). According to the results obtained, a more sustained and consistent rate of release of the drug was observed over time in the case of liposomes, regardless of the medium. In PBS and SPF media, a greater amount of drug was released from the larger liposomes (0.45 microns), however, in the SBF the transfer kinetics of both liposome sizes (0.45µm and 0.20 µm) are very similar, with no significant differences in the time or amount of drug released.
spa
info:eu-repo/semantics/openAccess
Liposomoes
Sildenafil
Biorelevant media
pulmonary hypertension
Liposomas
Sildenafilo
Medios biorrelevantes
hipertensión pulmonar
Cesión de fármacos desde liposomas en distintos medios biorrelevantes
info:eu-repo/semantics/article
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ZXN1cG9uZSBxdWUgc2UgaGEgY3VtcGxpZG8gY29uIGN1YWxxdWllciBkZXJlY2hvIGRlIHJldmlzacOzbiB1IG90cmFzIG9ibGlnYWNpb25lcyByZXF1ZXJpZGFzIHBvciBlc3RlIGNvbnRyYXRvIG8gYWN1ZXJkby4KCjcuTGEgVW5pdmVyc2lkYWQgZGUgU2FsYW1hbmNhIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBzdS9zIG5vbWJyZS9zIGNvbW8gZWwvbG9zIGF1dG9yL2VzIG8gcHJvcGlldGFyaW8vcyBkZSBsb3MgZGVyZWNob3MgZGVsIGRvY3VtZW50bywgeSBubyBoYXLDoSBuaW5ndW5hIGFsdGVyYWNpw7NuIGRlIHN1IGRvY3VtZW50byBkaWZlcmVudGUgYSBsYXMgcGVybWl0aWRhcyBlbiBlc3RhIGxpY2VuY2lhLg==
URL
https://gredos.usal.es/bitstream/10366/146526/1/Cesion_de_farmacos_desde_liposomas_en_di.pdf
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Cesion_de_farmacos_desde_liposomas_en_di.pdf
URL
https://gredos.usal.es/bitstream/10366/146526/5/Cesion_de_farmacos_desde_liposomas_en_di.pdf.txt
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MD5
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Cesion_de_farmacos_desde_liposomas_en_di.pdf.txt