2026-09-10T13:43:46Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1466062025-04-30T20:50:15Zcom_10366_4613com_10366_4576com_10366_3823col_10366_4615

Mangas, Arturo Heredia Chons, Margarita Sánchez Riolobos, Adelaida Fuente Juan, Antonio de la Criado Gutiérrez, José María Yajeya, Javier Geffard, Michel Coveñas Rodríguez, Rafael 2021-05-31T11:26:07Z 2021-05-31T11:26:07Z 2018 Mangas, A., Heredia, M., Riolobos, A., de la Fuente, A., Criado, J. M., Yajeya, J., Geffard, M., & Coveñas, R. (2018). Overexpression of kynurenic acid and 3-hydroxyanthranilic acid after rat traumatic brain injury. European Journal of Histochemistry, 62(4). https://doi.org/10.4081/ejh.2018.2985 1121-760X http://hdl.handle.net/10366/146606 10.4081/ejh.2018.2985 2038-8306 [EN]Using an immunohistochemical technique, we have studied the distribution of kynuneric acid (KYNA) and 3-hydroxyanthranilic acid (3-HAA) in a rat brain injury model (trauma). The study was carried out inducing a cerebral ablation of the frontal motor cortex. Two mouse monoclonal specific antibodies previously developed by our group directed against KYNA and 3-HAA were used. In control animals (sham-operated), the expression of both KYNA and 3-HAA was not observed. In animals in which the ablation was performed, the highest number of immunoreactive cells containing KYNA or 3-HAA was observed in the region surrounding the lesion and the number of these cells decreased moving away from the lesion. KYNA and 3-HAA were also observed in the white matter (ipsilateral side) located close to the injured region and in some cells placed in the white matter of the contralateral side. The distribution of KYNA and 3-HAA perfectly matched with the peripheral injured regions. The results found were identical independently of the perfusion date of animals (17, 30 or 54 days after brain injury). For the first time, the presence of KYNA and 3-HAA has been described in a rat trauma model. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional 3-OH-anthranilic acid Astrocytes Glia Immunohistochemistry Kynurenic acid Neurotoxicity Trauma Overexpression of kynurenic acid and 3-hydroxyanthranilic acid after rat traumatic brain injury info:eu-repo/semantics/article