2026-09-14T14:37:12Zhttps://gredos.usal.es/oai/requestoai:gredos.usal.es:10366/1484002025-04-30T19:51:21Zcom_10366_4155com_10366_4055com_10366_3946com_10366_3823com_10366_4756com_10366_4746com_10366_143088com_10366_123103col_10366_4163col_10366_68518col_10366_143114
Gestión del Repositorio Documental de la Universidad de Salamanca
advisor
Rodríguez Morán, Joaquín
advisor
Marcos Monleón, Laura
advisor
Fuentes de Arriba, Ángel Luis
author
Garrido González, José Javier
2022-01-27T09:58:53Z
2022-01-27T09:58:53Z
2021
http://hdl.handle.net/10366/148400
10.14201/gredos.148400
[EN]The general objective of this Thesis is the design and synthesis of small organic molecules which mimic the oxyanion-hole scaffold found in hydrolytic enzymes. They employ this structural motif to associate anions and electronegative groups such as carbonyls from esters and amides and reduce the activation energy of many reactions in which a negatively-charged transition state is generated.
These artificial oxyanion-hole mimic will be used to associate the carboxylic acid group of amino acids in order to carry out the chiral resolution of racemic mixtures of amino acids. In addition, they will be employed to catalyse the transesterification of non-activated esters by mimicking the mechanism of natural hydrolases
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Tesis y disertaciones académicas
Universidad de Salamanca (España)
Tesis Doctoral
Academic dissertations
Catálisis orgánica
Receptores
Receptores moleculares que simulan agujeros oxianiónicos: reconocimiento molecular y catálisis
info:eu-repo/semantics/doctoralThesis
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URL
https://gredos.usal.es/bitstream/10366/148400/1/PDCTQ_GarridoGonz%c3%a1lezJJ_Receptoresmoleculares.pdf
File
MD5
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application/pdf
PDCTQ_GarridoGonzálezJJ_Receptoresmoleculares.pdf
URL
https://gredos.usal.es/bitstream/10366/148400/6/PDCTQ_GarridoGonz%c3%a1lezJJ_Receptoresmoleculares.pdf.txt
File
MD5
ccb8bc607b2619f8aabcb865db39e007
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text/plain
PDCTQ_GarridoGonzálezJJ_Receptoresmoleculares.pdf.txt