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oai:gredos.usal.es:10366/1540802026-06-20T10:24:53Zcom_10366_4019com_10366_3947com_10366_3946com_10366_3823col_10366_4020

Differences between alcoholic and nonalcoholic patients with Wernicke encephalopathy: a multicenter observational study Chamorro Fernández, Antonio Javier Rosón Hernández, Beatriz Medina García, José-A. Muga Bustamante, Roberto Fernández Solá, Joaquín Martín González, M. Candelaria Seco Hernández, Elena Novo Veleiro, Ignacio Suárez Cuervo, Carlos Mateos Díaz, Ana M. Monte Secades, Rafael Machado Prieto, Begoña Puerta Louro, Rubén Prada González, Cristina Fernández Rial, Álvaro Sabio Repiso, Patricia Vázquez Vigo, Rocío Antolí Royo, Ana Cristina Gomila Grange, Aina Felipe Pérez, Nieves-C. Sanvisens Bergé, Arantza Antúnez Jorge, Emilia Fernández Rodríguez, Camino-M. Alvela-Suárez, Lucía Fidalgo Navarro, Alba Marcos Martín, Miguel Castro, Joaquín Polvorosa Gómez, María A. del Valle Sánchez, Mario Lopez Castro, José González Quintela, Arturo Laso Guzmán, Francisco Javier Nonalcoholic patients Alcoholic patients Wernicke encephalopathy Wernicke Encephalopathy Alcoholics 6113.01 Alcoholismo alcohólicos encefalopatía de Wernicke [EN]Objective: To analyze the differences in characteristics and prognosis between alcoholic and nonalcoholic patients with Wernicke encephalopathy (WE). Patients and Methods: A retrospective observational cohort of 468 patients diagnosed with WE with at least 2 Caine criteria was selected from all patients discharged with a diagnosis of WE from 21 medical centers in Spain from January 1, 2000, through December 31, 2012. Demographic, clinical, and outcome variables were described. Results: Among the 468 patients, the most common risk factor was alcoholism (n¼434 [92.7%]). More than one-third of patients (n¼181 [38.7%]) had the classic WE triad of symptoms (ocular signs, cerebellar dysfunction, and confusion). Among 252 patients for whom magnetic resonance imaging data were available, 135 (53.6%) had WE-related lesions and 42 (16.7%) had cerebellar lesions. Of the 468 patients, 25 (5.3%) died during hospitalization. Alcoholic patients presented more frequently than nonalcoholic patients with cerebellar signs (P¼.01) but less frequently with ocular signs (P¼.02). Alcoholic patients had a significantly higher frequency of hyponatremia (P¼.04) and decreased platelet count (P¼.005) compared with nonalcoholics. Alcoholic patients were diagnosed earlier than nonalcoholics (median time to diagnosis, 1 vs 4 days; P¼.001) and had shorter hospitalizations (13 vs 23 days; P¼.002). Conclusion: Compared with nonalcoholic patients, alcoholic patients with WE are more likely to present with cerebellar signs and less likely to have ocular signs. Diagnosis may be delayed in nonalcoholic patients. Mortality in the present series was lower than described previously. 2024-01-10T09:29:13Z 2024-01-10T09:29:13Z 2017 2099-09-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Chamorro, A. J., Rosón-Hernández, B., Medina-García, J. A., Muga-Bustamante, R., Fernández-Solá, J., Martín-González, M. C., ... & Spanish Society of Internal Medicine (SEMI. (2017, June). Differences between alcoholic and nonalcoholic patients with Wernicke encephalopathy: a multicenter observational study. In Mayo Clinic Proceedings (Vol. 92, No. 6, pp. 899-907). Elsevier. https://doi.org/10.1016/j.mayocp.2017.02.019 0025-6196 http://hdl.handle.net/10366/154080 10.1016/j.mayocp.2017.02.019 eng https://doi.org/10.1016/j.mayocp.2017.02.019 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/embargoedAccess Elsevier https://gredos.usal.es/bitstream/10366/154080/4/MCP%2017.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by-nc-nd/4.0/ Gredos. Repositorio Documental de la Universidad de Salamanca http://hdl.handle.net/10366/154080