2026-08-28T05:42:35Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1541292025-04-30T20:39:55Zcom_10366_154031com_10366_4512com_10366_3823col_10366_154034

Benito León, Julián Contador Castillo, Israel Vega, Saturio Villarejo Galende, Alberto Bermejo Pareja, Félix 2024-01-11T15:21:59Z 2024-01-11T15:21:59Z 2019-09-17 Benito-León J, Contador I, Vega S, Villarejo-Galende A, Bermejo-Pareja F. (2019). Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer's disease mortality. PLoS One, 14(9):e0222505. Doi: 10.1371/journal.pone.0222505 1932-6203 http://hdl.handle.net/10366/154129 10.1371/journal.pone.0222505 [EN]Alzheimer disease (AD) mortality risk in a large cohort of subjects treated or not with non-steroidal anti-inflammatory drugs (NSAIDs) is unknown. Our objective was to determine whether NSAIDs use is associated with decreased risk of AD mortality. In this prospective, population-based study (Neurological Disorders in Central Spain [NEDICES]) of 5,072 people without AD (aged 65 years and older), sociodemographic, comorbidity factors, and current medications were recorded at baseline. Community-dwelling older adults were followed for a median of 12.7 years, after which the death certificates of deceased participants were examined. 2,672 (52.7%) of 5,072 participants died, including 504 (18.9%) NSAIDs users and 2,168 (81.1%) non-users. Of the 2,672 deceased participants, 113 (4.2%) had AD as a cause of death (8 [1.6%] among NSAIDs users and 105 [4.8%] among non-users, chi-square = 10.70, p = 0.001). In an unadjusted Cox model, risk of AD mortality was decreased in NSAIDs users (hazard ratio [HR] for AD mortality = 0.35, 95% confidence interval [CI] 0.17–0.72, p = 0.004) when compared to non-users. After adjusting for numerous demographic factors and co-morbidities, the HR for AD mortality in NSAIDs users was 0.29, 95% CI 0.12–0.73, p = 0.009. Stratified analyses showed a significantly decreased risk of AD mortality with aspirin, whereas non-aspirin NSAIDs only showed a statistical trend toward significance in the adjusted Cox regression models. NSAIDs use was associated with 71% decreased risk of AD mortality in older adults. Our results support the hypothesis that NSAIDs use is a protective factor of developing AD. eng info:eu-repo/semantics/openAccess Alzheimer's disease Mortality Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer's disease mortality. info:eu-repo/semantics/article