2026-09-16T00:56:57Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1541722025-04-30T20:39:54Zcom_10366_154031com_10366_4512com_10366_3823col_10366_154034

Contador Castillo, Israel Alzola, Patricia Bermejo Pareja, Félix Ser, Teodoro del Llamas Velasco, Sara Fernández Calvo, Bernardino Benito León, Julián 2022-06-28 [EN]Background:A protective effect of education on cognitive decline after stroke has been claimed, but evidence from prospective population-based cohorts is very limited. The differential role of literacy and education on dementia after stroke remains unexplored. Objective:This research addresses the role of education and literacy in dementia incidence after stroke and transient ischemic attack (TIA). Methods:131 participants with stroke or TIA were identified within the population-based NEDICES study (N = 5,278 persons). Participants were fully assessed at baseline (1994–1995) and incident dementia diagnosis was made by expert neurologists (DSM-IV criteria) after a mean follow-up of 3.4 years. Adjusted Cox regression analyses were applied to test the association between education, literacy, and dementia risk. Results:Within the 131 subjects with stroke or TIA, 19 (14%) developed dementia at follow-up. The Cox’s regression model (age and sex adjusted) showed that low education (HR = 3.48, 95% CI = 1.28, 9.42, p = 0.014) and literacy (HR = 3.16, 95% CI = 1.08, 9.22, p = 0.035) were significantly associated with a higher dementia risk. Low education was also associated with dementia when main confounders (i.e., cognitive/functional performance) were considered in the Cox’s model. However, after including stroke recurrence, only low/null literacy (versus education) remained as significant predictor of dementia. Finally, low/null literacy showed an effect over-and-above education on dementia risk when both factors were introduced in the adjusted Cox’s regression. Conclusion:These findings underline the importance of literacy to estimate cognitive decline after stroke in low-educated populations. http://hdl.handle.net/10366/154172 eng IOS Press Education and Literacy as Risk Factors of Dementia after Stroke and Transient Ischemic Attack: NEDICES Study. info:eu-repo/semantics/article TEXT Gredos. Repositorio Documental de la Universidad de Salamanca Hispana