2026-09-15T14:37:39Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1546792025-04-30T19:23:24Zcom_10366_3948com_10366_3947com_10366_3946com_10366_3823col_10366_3949

Hernández, José Ángel Benito Sánchez, Rocío García, Juan Luis Hernández-Sánchez, María Risueño, Alberto Sarasquete, M. Eugenia Fermiñán, Encarna Fisac, Rosa de Coca, Alfonso García Martín-Núñez, Guillermo de las Heras, Natalia Recio, Isabel Gutiérrez, Oliver Rivas Sanz, Javier de las González, Marcos Hernández Rivas, Jesús María Rodríguez-Vicente, Ana E. Gutiérrez Gutiérrez, Norma Carmen 2024-01-25T09:29:39Z 2024-01-25T09:29:39Z 2012 Rodríguez-Vicente, A.E., Hernández, J.A., Benito, R., Gutiérrez, N.C. García, J.L., Hernández Sánchez, M., Risueño, A., Sarasquete, M.E., Fermiñán, E., Fisac, R., García de Coca, A., Martín-Núñez, G., Heras, N., Recio, I., Gutiérrez, O., Rivas, J., González, M., Hernández-Rivas., J.M. (2012). Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14. PLoS ONE, 7 (11) pp 1-13. https://doi.org/10.1371/journal.pone.0048485 http://hdl.handle.net/10366/154679 10.1371/journal.pone.0048485 1932-6203 [EN] Background: Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods:: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Results: Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (.80%) showed a different level of gene expression as compared to patients with lower percentages (,80%, 13q-L). This deregulation affected genes involved in apoptosis and proliferation (BCR and NFkB signaling), leading to increased proliferation and decreased apoptosis in 13q-H patients. Deregulation of several microRNAs, such as miR-15a, miR-155, miR-29a and miR-223, was also observed in these patients. In addition, our study also suggests that the gene expression pattern of 13q-H cases could be similar to the patients with 11q- or 17p-. Conclusions: This study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher percentages of 13q- cells. eng Board Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Linfocitos Paciente Leucemia Caracterización molecular Leukemia Patients Lymphocytes 6310.03 Enfermedad 2410.02 Anatomía Humana leucemia pacientes linfocitos Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.1371/journal.pone.0048485 PLoS ONE 7 11 1 13