2026-09-08T02:28:22Zhttps://gredos.usal.es/oai/request

oai:gredos.usal.es:10366/1547052026-06-20T14:57:29Zcom_10366_3966com_10366_3947com_10366_3946com_10366_3823col_10366_3967

Vicente Vicente, Rosa Laura Sánchez Juanes, Fernando García Sánchez, Omar Blanco Gozalo, Víctor Pescador Garriel, Moisés Sevilla Toral, María Ángeles González de Buitrago Arriero, José Manuel López Hernández, Francisco José López-Novoa, José M. Morales Martín, Ana Isabel 2015-04-16 [EN]Nephrotoxicity limits the therapeutic efficacy of the antineoplastic drug cisplatin. Due to dosage adjustment and appropriate monitoring, most therapeutic courses with cisplatin produce no or minimal kidney damage. However, we studied whether even sub-nephrotoxic dosage of cisplatin poses a potential risk for the kidneys by predisposing to acute kidney injury (AKI), specifically by lowering the toxicity threshold for a second nephrotoxin. With this purpose rats were treated with a single sub-nephrotoxic dosage of cisplatin (3mg/kg, i.p.) and after two days, with a sub-nephrotoxic regime of gentamicin (50mg/kg/day, during 6 days, i.p.). Control groups received only one of the drugs or the vehicle. Renal function and renal histology were monitored throughout the experiment. Cisplatin treatment did not cause any relevant functional or histological alterations in the kidneys. Rats treated with cisplatin and gentamicin, but not those under single treatments, developed an overt renal failure characterized by both renal dysfunction and massive tubular necrosis. In addition, the urinary excretion of fumarylacetoacetase was increased in cisplatin-treated animals at subtoxic doses, which might be exploited as a cisplatin-induced predisposition marker. In fact, the urinary level of fumarylacetoacetase prior to the second nephrotoxin correlated with the level of AKI triggered by gentamicin in predisposed animals. http://hdl.handle.net/10366/154705 eng Elsevier Sub-nephrotoxic cisplatin sensitizes rats to acute renal failure and increases urinary excretion of fumarylacetoacetase info:eu-repo/semantics/article TEXT Gredos. Repositorio Documental de la Universidad de Salamanca Hispana